TY - JOUR
T1 - Chemical and photochemical probing of DNA complexes
AU - Nielsen, Peter E.
PY - 1990/2
Y1 - 1990/2
N2 - An overview of the chemical and photochemical probes which over the past ten years have been used in studies of DNA/ligand complexes and of non-B-form DNA conformations is presented with emphasis on the chemical reactions of the probes with DNA and on their present 'use-profile'. The chemical probes include: dimethyl sulfate, ethyl nitroso urea, diethyl pyrocarbonate, osmium tetroxide, permanganate, aldehydes, methidiumpropyl-EDTA-Fell (MPE), phenanthroline metal complexes and EDTA/FeII. The photochemical probes that have been used include: psoralens, UVB, acridines and uranyl salts. The biological systems analysed by use of these probes are reviewed by tabulation.
AB - An overview of the chemical and photochemical probes which over the past ten years have been used in studies of DNA/ligand complexes and of non-B-form DNA conformations is presented with emphasis on the chemical reactions of the probes with DNA and on their present 'use-profile'. The chemical probes include: dimethyl sulfate, ethyl nitroso urea, diethyl pyrocarbonate, osmium tetroxide, permanganate, aldehydes, methidiumpropyl-EDTA-Fell (MPE), phenanthroline metal complexes and EDTA/FeII. The photochemical probes that have been used include: psoralens, UVB, acridines and uranyl salts. The biological systems analysed by use of these probes are reviewed by tabulation.
KW - DNA
KW - Indicators and Reagents
KW - Models, Molecular
KW - Molecular Probes
KW - Nucleic Acid Conformation
KW - Photochemistry
U2 - 10.1002/jmr.300030102
DO - 10.1002/jmr.300030102
M3 - Review
C2 - 2191698
SN - 0952-3499
VL - 3
SP - 1
EP - 25
JO - Journal of Molecular Recognition
JF - Journal of Molecular Recognition
IS - 1
ER -