Characterization of sequence variations in the D21S11 locus in Danes, Somalis and Greenlanders by second generation sequencing

Eszter Rockenbauer, Stine Hansen, Malene Rask Andersen, Emilie Heerup, Claus Børsting, Sarah Louise Fordyce, Niels Morling

3 Citations (Scopus)

Abstract

We used second generation sequencing to investigate the sequence variation and allele frequencies of D21S11 alleles in three geographically distant populations: Danes, Somalis and Greenlanders. Samples from 127 unrelated individuals (47 Danes, 57 Somalis and 23 Greenlanders) from Danish paternity and immigration cases were sequenced. In total, 36 allele variants with 14 different lengths were identified among the 256 alleles. The highest degree of variation was found in Somalis and the lowest one in Greenlanders. The number of repeats within the first and third variable repeat regions of the D21S11 locus had the highest variation between the samples investigated. This variation seemed to be population specific. The high sequence variation observed within the 127 subjects and within the three ethnic groups demonstrated the discriminatory power of the D21S11 STR system.

Original languageEnglish
JournalForensic Science International: Genetics. Supplement Series
Volume4
Issue number1
Pages (from-to)e302-e303
Number of pages2
ISSN1875-1768
Publication statusPublished - 31 Oct 2013
Event25’th congress of the International Society of Forensic Genetics - Melbourne, Australia
Duration: 2 Sept 20137 Sept 2013

Conference

Conference25’th congress of the International Society of Forensic Genetics
Country/TerritoryAustralia
CityMelbourne
Period02/09/201307/09/2013

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