Characterization of alginates by nuclear magnetic resonance (NMR) and vibrational spectroscopy (IR, NIR, Raman) in combination with chemometrics

Henrik Max Jensen, Flemming Hofmann Larsen, Søren Balling Engelsen

15 Citations (Scopus)

Abstract

This chapter describes three different spectroscopic methods for structural characterization of the commercial important hydrocolloid alginate extracted from brown seaweed. The “golden” reference method for characterization of the alginate structure is1H liquid-state NMR of depolymerized alginate polymers using a stepwise hydrolysis. Having implemented this method, predictive and rapid non-destructive methods using vibrational spectroscopy and chemometrics can be developed. These methods can predict the M/G-ratio of the intact alginate powder with at least the same precision and accuracy as the reference method in a fraction of the time that is required to measure the alginate using the reference method. The chapter also demonstrates how solid-state13C CP/MAS NMR can be used to determine the M/G ratio on the intact sample by the use of multivariate chemometrics and how this method shares the characteristics of the solid-state non-destructive IR method rather than its liquid-state counterpart.

Original languageEnglish
Title of host publicationNatural products from marine algae : methods and protocols
EditorsDagmar B. Stengel, Solène Connan
Number of pages17
Volume1308
PublisherSpringer
Publication date2015
Pages347-363
Chapter22
ISBN (Print)978-1-4939-2683-1
ISBN (Electronic)978-1-4939-2684-8
DOIs
Publication statusPublished - 2015
SeriesMethods in Molecular Biology
Volume1308
ISSN1064-3745

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