C/EBPalpha in leukemogenesis: Identity and origin of the leukemia-initiating cell

TY - JOUR

T1 - C/EBPalpha in leukemogenesis: Identity and origin of the leukemia-initiating cell

AU - Schuster, Mikkel Bruhn

AU - Porse, Bo Torben

PY - 2009

Y1 - 2009

N2 - The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBPalpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPalpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.

AB - The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBPalpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPalpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.

U2 - 10.1002/biof.36

DO - 10.1002/biof.36

M3 - Journal article

C2 - 19322763

SN - 0951-6433

VL - 35

SP - 227

EP - 231

JO - BioFactors

JF - BioFactors

IS - 3

ER -