TY - JOUR
T1 - C/EBPalpha in leukemogenesis: Identity and origin of the leukemia-initiating cell
AU - Schuster, Mikkel Bruhn
AU - Porse, Bo Torben
PY - 2009
Y1 - 2009
N2 - The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBPalpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPalpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.
AB - The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBPalpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPalpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.
U2 - 10.1002/biof.36
DO - 10.1002/biof.36
M3 - Journal article
C2 - 19322763
SN - 0951-6433
VL - 35
SP - 227
EP - 231
JO - BioFactors
JF - BioFactors
IS - 3
ER -