CDy14: A novel biofilm probe targeting exopolysaccharide Psl

Haw Young Kwon; Jun Young Kim; Jung Yeol Lee; Joey Kuok Hoong Yam; Louise Dahl Hultqvist; Wang Xu; Morten Rybtke; Tim Tolker-Nielsen; Jong Jin Kim; Nam Young Kang; Liang Yang; Sung Jin Park; Michael Givskov; Young Tae Chang

doi:10.1039/c8cc05544k

CDy14: A novel biofilm probe targeting exopolysaccharide Psl

Haw Young Kwon, Jun Young Kim, Jung Yeol Lee, Joey Kuok Hoong Yam, Louise Dahl Hultqvist, Wang Xu, Morten Rybtke, Tim Tolker-Nielsen, Jong Jin Kim, Nam Young Kang, Liang Yang, Sung Jin Park^*, Michael Givskov, Young Tae Chang

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

Original language	English
Journal	Chemical Communications
Volume	54
Issue number	84
Pages (from-to)	11865-11868
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c8cc05544k
Publication status	Published - 2018

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title = "CDy14: A novel biofilm probe targeting exopolysaccharide Psl",

abstract = "Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.",

author = "Kwon, {Haw Young} and Kim, {Jun Young} and Lee, {Jung Yeol} and Yam, {Joey Kuok Hoong} and Hultqvist, {Louise Dahl} and Wang Xu and Morten Rybtke and Tim Tolker-Nielsen and Kim, {Jong Jin} and Kang, {Nam Young} and Liang Yang and Park, {Sung Jin} and Michael Givskov and Chang, {Young Tae}",

year = "2018",

doi = "10.1039/c8cc05544k",

language = "English",

volume = "54",

pages = "11865--11868",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - CDy14

T2 - A novel biofilm probe targeting exopolysaccharide Psl

AU - Kwon, Haw Young

AU - Kim, Jun Young

AU - Lee, Jung Yeol

AU - Yam, Joey Kuok Hoong

AU - Hultqvist, Louise Dahl

AU - Xu, Wang

AU - Rybtke, Morten

AU - Tolker-Nielsen, Tim

AU - Kim, Jong Jin

AU - Kang, Nam Young

AU - Yang, Liang

AU - Park, Sung Jin

AU - Givskov, Michael

AU - Chang, Young Tae

PY - 2018

Y1 - 2018

N2 - Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

AB - Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

U2 - 10.1039/c8cc05544k

DO - 10.1039/c8cc05544k

M3 - Journal article

C2 - 30204158

AN - SCOPUS:85055076861

SN - 1359-7345

VL - 54

SP - 11865

EP - 11868

JO - Chemical Communications

JF - Chemical Communications

IS - 84

ER -

CDy14: A novel biofilm probe targeting exopolysaccharide Psl

Abstract

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