Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

Mette Burmølle; Trine Rolighed Thomsen; Mustafa Fazli; Irene Dige; Lise Christensen; Preben Homøe; Michael Tvede; Bente Nyvad; Tim Tolker-Nielsen; Michael Givskov; Claus Ernst Moser; Klaus Kirketerp-Møller; Helle Krogh Johansen; Niels Høiby; Peter Østrup Jensen; Søren Johannes Sørensen; Thomas Bjarnsholt

doi:10.1111/j.1574-695x.2010.00714.x

Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

Mette Burmølle, Trine Rolighed Thomsen, Mustafa Fazli, Irene Dige, Lise Christensen, Preben Homøe, Michael Tvede, Bente Nyvad, Tim Tolker-Nielsen, Michael Givskov, Claus Ernst Moser, Klaus Kirketerp-Møller, Helle Krogh Johansen, Niels Høiby, Peter Østrup Jensen, Søren Johannes Sørensen, Thomas Bjarnsholt

231 Citations (Scopus)

Abstract

It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.

Translated title of the contribution	Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
Original language	English
Journal	FEMS Immunology and Medical Microbiology
Volume	59
Issue number	3
Pages (from-to)	324-336
Number of pages	13
ISSN	0928-8244
DOIs	https://doi.org/10.1111/j.1574-695x.2010.00714.x
Publication status	Published - Aug 2010

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Burmølle, M., Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, P., Tvede, M., Nyvad, B., Tolker-Nielsen, T., Givskov, M., Moser, C. E., Kirketerp-Møller, K., Johansen, H. K., Høiby, N., Jensen, P. Ø., Sørensen, S. J., & Bjarnsholt, T. (2010). Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections. FEMS Immunology and Medical Microbiology, 59(3), 324-336. https://doi.org/10.1111/j.1574-695x.2010.00714.x

Burmølle, M, Thomsen, TR, Fazli, M, Dige, I, Christensen, L, Homøe, P, Tvede, M, Nyvad, B, Tolker-Nielsen, T , Givskov, M , Moser, CE, Kirketerp-Møller, K, Johansen, HK , Høiby, N , Jensen, PØ , Sørensen, SJ & Bjarnsholt, T 2010, 'Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections', FEMS Immunology and Medical Microbiology, vol. 59, no. 3, pp. 324-336. https://doi.org/10.1111/j.1574-695x.2010.00714.x

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abstract = "It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.",

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AU - Burmølle, Mette

AU - Thomsen, Trine Rolighed

AU - Fazli, Mustafa

AU - Dige, Irene

AU - Christensen, Lise

AU - Homøe, Preben

AU - Tvede, Michael

AU - Nyvad, Bente

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

AU - Moser, Claus Ernst

AU - Kirketerp-Møller, Klaus

AU - Johansen, Helle Krogh

AU - Høiby, Niels

AU - Jensen, Peter Østrup

AU - Sørensen, Søren Johannes

AU - Bjarnsholt, Thomas

PY - 2010/8

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N2 - It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.

AB - It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.

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KW - chronic infections

KW - diagnostics

KW - IN-SITU HYBRIDIZATION

KW - VENOUS LEG ULCERS

KW - NONTYPABLE HAEMOPHILUS-INFLUENZAE

KW - PSEUDOMONAS-AERUGINOSA BIOFILMS

KW - INITIAL DENTAL BIOFILM

KW - BACTERIAL DIVERSITY

KW - CHRONIC WOUNDS

KW - POLYMORPHONUCLEAR LEUKOCYTES

KW - OTITIS-MEDIA

KW - MIDDLE-EAR

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DO - 10.1111/j.1574-695x.2010.00714.x

M3 - Review

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SN - 2049-632X

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SP - 324

EP - 336

JO - Pathogens and Disease

JF - Pathogens and Disease

IS - 3

ER -

Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

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