TY - JOUR
T1 - Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
AU - Burmølle, Mette
AU - Thomsen, Trine Rolighed
AU - Fazli, Mustafa
AU - Dige, Irene
AU - Christensen, Lise
AU - Homøe, Preben
AU - Tvede, Michael
AU - Nyvad, Bente
AU - Tolker-Nielsen, Tim
AU - Givskov, Michael
AU - Moser, Claus Ernst
AU - Kirketerp-Møller, Klaus
AU - Johansen, Helle Krogh
AU - Høiby, Niels
AU - Jensen, Peter Østrup
AU - Sørensen, Søren Johannes
AU - Bjarnsholt, Thomas
PY - 2010/8
Y1 - 2010/8
N2 - It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.
AB - It has become evident that aggregation or biofilm formation is an important survival mechanism for bacteria in almost any environment. In this review, we summarize recent visualizations of bacterial aggregates in several chronic infections (chronic otitis media, cystic fibrosis, infection due to permanent tissue fillers and chronic wounds) both as to distribution (such as where in the wound bed) and organization (monospecies or multispecies microcolonies). We correlate these biofilm observations to observations of commensal biofilms (dental and intestine) and biofilms in natural ecosystems (soil). The observations of the chronic biofilm infections point toward a trend of low bacterial diversity and sovereign monospecies biofilm aggregates even though the infection in which they reside are multispecies. In contrast to this, commensal and natural biofilm aggregates contain multiple species that are believed to coexist, interact and form biofilms with high bacterial and niche diversity. We discuss these differences from both the diagnostic and the scientific point of view.
KW - biofilm
KW - chronic infections
KW - diagnostics
KW - IN-SITU HYBRIDIZATION
KW - VENOUS LEG ULCERS
KW - NONTYPABLE HAEMOPHILUS-INFLUENZAE
KW - PSEUDOMONAS-AERUGINOSA BIOFILMS
KW - INITIAL DENTAL BIOFILM
KW - BACTERIAL DIVERSITY
KW - CHRONIC WOUNDS
KW - POLYMORPHONUCLEAR LEUKOCYTES
KW - OTITIS-MEDIA
KW - MIDDLE-EAR
U2 - 10.1111/j.1574-695x.2010.00714.x
DO - 10.1111/j.1574-695x.2010.00714.x
M3 - Review
C2 - 20602635
SN - 0928-8244
VL - 59
SP - 324
EP - 336
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
IS - 3
ER -