Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Andreas Willerslev-Olsen; Thorbjørn Krejsgaard; Lise Maria Lindahl; Charlotte Menne Bonefeld; Mariusz A Wasik; Sergei B Koralov; Carsten Geisler; Mogens Kilian; Lars Iversen; Anders Woetmann; Niels Odum

doi:10.3390/toxins5081402

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise Maria Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Department of Immunology and Microbiology

43 Citations (Scopus)

Abstract

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

Original language	English
Journal	Toxins
Volume	5
Issue number	8
Pages (from-to)	1402-21
Number of pages	20
ISSN	2072-6651
DOIs	https://doi.org/10.3390/toxins5081402
Publication status	Published - Aug 2013

Keywords

Bacterial Infections
Bacterial Toxins
Cytokines
Disease Progression
Drug Resistance, Bacterial
Enterotoxins
Genes, T-Cell Receptor beta
Humans
Lymphoma, T-Cell, Cutaneous
Morbidity
Prevalence
Skin Neoplasms
Staphylococcus aureus
T-Lymphocytes

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10.3390/toxins5081402

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title = "Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma",

abstract = "In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.",

keywords = "Bacterial Infections, Bacterial Toxins, Cytokines, Disease Progression, Drug Resistance, Bacterial, Enterotoxins, Genes, T-Cell Receptor beta, Humans, Lymphoma, T-Cell, Cutaneous, Morbidity, Prevalence, Skin Neoplasms, Staphylococcus aureus, T-Lymphocytes",

author = "Andreas Willerslev-Olsen and Thorbj{\o}rn Krejsgaard and Lindahl, {Lise Maria} and Bonefeld, {Charlotte Menne} and Wasik, {Mariusz A} and Koralov, {Sergei B} and Carsten Geisler and Mogens Kilian and Lars Iversen and Anders Woetmann and Niels Odum",

year = "2013",

month = aug,

doi = "10.3390/toxins5081402",

language = "English",

volume = "5",

pages = "1402--21",

journal = "Toxins",

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T1 - Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

AU - Willerslev-Olsen, Andreas

AU - Krejsgaard, Thorbjørn

AU - Lindahl, Lise Maria

AU - Bonefeld, Charlotte Menne

AU - Wasik, Mariusz A

AU - Koralov, Sergei B

AU - Geisler, Carsten

AU - Kilian, Mogens

AU - Iversen, Lars

AU - Woetmann, Anders

AU - Odum, Niels

PY - 2013/8

Y1 - 2013/8

N2 - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

AB - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

KW - Bacterial Infections

KW - Bacterial Toxins

KW - Cytokines

KW - Disease Progression

KW - Drug Resistance, Bacterial

KW - Enterotoxins

KW - Genes, T-Cell Receptor beta

KW - Humans

KW - Lymphoma, T-Cell, Cutaneous

KW - Morbidity

KW - Prevalence

KW - Skin Neoplasms

KW - Staphylococcus aureus

KW - T-Lymphocytes

U2 - 10.3390/toxins5081402

DO - 10.3390/toxins5081402

M3 - Journal article

C2 - 23949004

SN - 2072-6651

VL - 5

SP - 1402

EP - 1421

JO - Toxins

JF - Toxins

IS - 8

ER -

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Abstract

Keywords

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