Abstract
The synthesis of [3H]chloramphenicol and its erythro-diastereoisomer with specific activities of 1.25 Ci/mmol, and the further transformation of the [3H]chloramphenicol to a series of azido and diazo-substituted derivatives are described. The antibiotic activity of the compounds was considered insufficient for their use as photoaffinity labels.
Original language | English |
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Journal | Hoppe-Seyler's Zeitschrift fur Physiologische Chemie |
Volume | 360 |
Issue number | 6 |
Pages (from-to) | 721-4 |
Number of pages | 4 |
ISSN | 0018-4888 |
Publication status | Published - Jun 1979 |
Keywords
- Affinity Labels
- Chemical Phenomena
- Chemistry
- Chloramphenicol/analogs & derivatives
- Escherichia coli/drug effects
- Isotope Labeling/methods
- Ribosomes/drug effects
- Tritium