Analogues of [3H] chloramphenicol for photoaffinity labeling

V Leick, O Buchardt, Peter E. Nielsen

2 Citations (Scopus)

Abstract

The synthesis of [3H]chloramphenicol and its erythro-diastereoisomer with specific activities of 1.25 Ci/mmol, and the further transformation of the [3H]chloramphenicol to a series of azido and diazo-substituted derivatives are described. The antibiotic activity of the compounds was considered insufficient for their use as photoaffinity labels.

Original languageEnglish
JournalHoppe-Seyler's Zeitschrift fur Physiologische Chemie
Volume360
Issue number6
Pages (from-to)721-4
Number of pages4
ISSN0018-4888
Publication statusPublished - Jun 1979

Keywords

  • Affinity Labels
  • Chemical Phenomena
  • Chemistry
  • Chloramphenicol/analogs & derivatives
  • Escherichia coli/drug effects
  • Isotope Labeling/methods
  • Ribosomes/drug effects
  • Tritium

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