Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Jan O. Nehlin; Abbas Jafari; Michaela Tencerova; Moustapha Kassem

doi:10.1016/j.bone.2019.03.041

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Jan O. Nehlin^*, Abbas Jafari, Michaela Tencerova, Moustapha Kassem

^*Corresponding author for this work

Morphogenesis and Differentiation Program

9 Citations (Scopus)

Abstract

Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

Original language	English
Journal	Bone
ISSN	8756-3282
DOIs	https://doi.org/10.1016/j.bone.2019.03.041
Publication status	Published - Jun 2019

Keywords

Adiposity
Aging
Bone marrow stromal stem cells
Senescence
Signaling pathways

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10.1016/j.bone.2019.03.041

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title = "Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells",

abstract = "Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.",

keywords = "Adiposity, Aging, Bone marrow stromal stem cells, Senescence, Signaling pathways",

author = "Nehlin, {Jan O.} and Abbas Jafari and Michaela Tencerova and Moustapha Kassem",

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doi = "10.1016/j.bone.2019.03.041",

language = "English",

journal = "Bone",

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T1 - Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

AU - Nehlin, Jan O.

AU - Jafari, Abbas

AU - Tencerova, Michaela

AU - Kassem, Moustapha

PY - 2019/6

Y1 - 2019/6

N2 - Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

AB - Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

KW - Adiposity

KW - Aging

KW - Bone marrow stromal stem cells

KW - Senescence

KW - Signaling pathways

U2 - 10.1016/j.bone.2019.03.041

DO - 10.1016/j.bone.2019.03.041

M3 - Journal article

C2 - 30946971

AN - SCOPUS:85064173743

SN - 8756-3282

JO - Bone

JF - Bone

ER -

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Abstract

Keywords

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