A lncRNA to repair DNA

Jiri Lukas; Matthias Altmeyer

doi:10.15252/embr.201541309

A lncRNA to repair DNA

Jiri Lukas, Matthias Altmeyer

Novo Nordisk Foundation Center for Protein Research

11 Citations (Scopus)

Abstract

Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

Original language	English
Journal	E M B O Reports
Volume	16
Issue number	11
Pages (from-to)	1413-4
Number of pages	2
ISSN	1469-221X
DOIs	https://doi.org/10.15252/embr.201541309
Publication status	Published - Nov 2015

Keywords

BRCA1 Protein
DNA Damage
Homologous Recombination
Humans
RNA, Long Noncoding
Comment
Journal Article

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10.15252/embr.201541309

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abstract = "Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.",

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AU - Altmeyer, Matthias

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AB - Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

KW - BRCA1 Protein

KW - DNA Damage

KW - Homologous Recombination

KW - Humans

KW - RNA, Long Noncoding

KW - Comment

KW - Journal Article

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DO - 10.15252/embr.201541309

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ER -

A lncRNA to repair DNA

Abstract

Keywords

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