A lncRNA to repair DNA

Jiri Lukas; Matthias Altmeyer

doi:10.15252/embr.201541309

A lncRNA to repair DNA

Jiri Lukas, Matthias Altmeyer

The NNF Center for Protein Research

11 Citationer (Scopus)

Abstract

Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

Originalsprog	Engelsk
Tidsskrift	E M B O Reports
Vol/bind	16
Udgave nummer	11
Sider (fra-til)	1413-4
Antal sider	2
ISSN	1469-221X
DOI	https://doi.org/10.15252/embr.201541309
Status	Udgivet - nov. 2015

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10.15252/embr.201541309

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title = "A lncRNA to repair DNA",

abstract = "Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.",

keywords = "BRCA1 Protein, DNA Damage, Homologous Recombination, Humans, RNA, Long Noncoding, Comment, Journal Article",

author = "Jiri Lukas and Matthias Altmeyer",

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year = "2015",

month = nov,

doi = "10.15252/embr.201541309",

language = "English",

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T1 - A lncRNA to repair DNA

AU - Lukas, Jiri

AU - Altmeyer, Matthias

PY - 2015/11

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AB - Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

KW - BRCA1 Protein

KW - DNA Damage

KW - Homologous Recombination

KW - Humans

KW - RNA, Long Noncoding

KW - Comment

KW - Journal Article

U2 - 10.15252/embr.201541309

DO - 10.15252/embr.201541309

M3 - Comment/debate

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VL - 16

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EP - 1414

JO - E M B O Reports

JF - E M B O Reports

IS - 11

ER -

A lncRNA to repair DNA

Abstract

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