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  • Øster Farimagsgade 5, 1014 København K, 05 Øster Farimagsgade 5, 05-2-01

20002019

Research activity per year

Personal profile

Current research

Research
The main topic of research is toxicological mechanisms of environmental exposures, including effects related to air pollution and particles, dietary factors, physiological processes in relation generation of reactive oxygen species and oxidative stress. This is mostly investigated as alterations of specific biomarkers of DNA damage, cardiovascular toxicity, and expression level of components in the antioxidant defense and DNA repair systems. The regulation of these protective systems is investigated in various experimental model systems, including transgenic models, and molecular epidemiology.     

Teaching

Miljømedicin (og toksikologi) ved medicin, folkesundhedsvidenskab og cand. scient. uddannelserne.

Primary fields of research

Arbejdsområder
Miljømedicin, toksikologi

Baggrund
Cand. scient i humanbiologi (1995) og Ph.D (2000) fra Københavns Universitet. Har arbejdet på Arbejdsmiljøinstituttet (1995-1999) og på Københavns Universitet, Institut for Folkesundhedsvidenskab som adjunkt (1999-2002), lektor (2002-2012) og professor (2012+).

Primære forskningsområder
Nanotoksikologi, oxidativ stress

Forskning
Forskningen har til formål at belyse toksikologiske virkningsmekanismer af miljøfaktorer og fysiologiske faktorer i et folkesundhedsmæssigt perspektiv. Et prioriteret indsatsområde er forskning i toksikologiske effekter af miljøfarlige stoffer, som forårsager dannelse af reaktive ilt radikaler (oksidativ stress) og oksidation af DNA. Derudover undersøges om forskellige oksidativ stress situationer påvirker regulationen af det antioksidante forsvarssystem og DNA reparationssystemet. Speciel fokus er rettet mod problemstillinger indenfor nano- og luftforureningspartiklers toksikologi i form af DNA beskadigende effekter og påvirkning af det kardiovaskulære system. Den forskningsmæssige metodik omfatter undersøgelser i cellekulturer og eksperimentelle modelsystemer hvor biologiske målinger (biomarkører) omfatter DNA skader, gen regulation på mRNA (RT-PCR) og protein niveau (immunohistokemi) og vasomotor dysfunktion.

CV

Academic: M.Sc (Human Biology), University of Copenhagen (1995),Ph. D, Faculty of Health Sciences, University of Copenhagen (2000), DMSc (Dr. Med.), Faculty of Health Sciences, University of Copenhagen (2005).

Employment: Research assistant (1995-1996) and Ph. D student (1995-1999) at the National Institute of Occupational Health, Denmark (1995-1996). Assistant Professor (1999-2002), Associate Professor (2002-2012) and Professor (2012+) at Institute of Public Health, University of Copenhagen

Supervision: Twenty-two master thesis and eighteen PhD fellowship students.

Publications: 215 articles in international peer-review journals. 15 articles in national journals and 11 book chapters.

Bibliography: 12.000 total citations (Scopus), H-index = 64, average impact factor = 4.9

Senior editor of Mutagenesis [Impact factor: 3.53], editorial board member of Particle and Fibre Toxicology [Impact factor: 9.18]. Guest Editor of Environmental Molecular Mutagenesis [Impact factor 3.078].

Other: Member of the Working Group for IARC Monograph volume 109 “Ambient Air Pollution” (Lancet Oncol vol 14, pp. 1262-1263, 2013) and Volume 111 “Some Nanomaterials and Some Fibres” (Lancet Oncol, Published online October 31, http://dx.doi.org/10.1016/S1470-2045(14)71109-X).

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • Faculty of Health and Medical Sciences
  • Environmental health
  • Toxicology
  • Nanotoxicology
  • Oxidative stress
  • DNA damage
  • DNA repair
  • Vascular function
  • Nanoparticles
  • Air pollution
  • Microplastic

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