Research output per year
Research output per year
Personal profile
Short presentation
The overall aim of my research is to understand how oxidative modifications impact on the structure and function of proteins. I am also investigating how these types of modifications influence the formation of supramolecular assemblies and protein aggregates.
A major focus area is the development of mass-spectrometry-based methodologies for qualitative and quantitative analysis of oxidative protein modifications, including intra- and intermolecular cross-links. I also have a long-standing interest in thioredoxins and thiol-disulphide exchange reactions.
Keywords
- Faculty of Health and Medical Sciences
- Protein oxidation, mass spectrometry, cross-linking, aggregation, supramolecular assemblies, proteomics
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Dive into the research topics where Per Mårten Hägglund is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Binding of rose bengal to lysozyme modulates photooxidation and cross-linking reactions involving tyrosine and tryptophan
Fuentes-Lemus, E., Mariotti, M., Hagglund, P., Leinisch, F., Fierro, A., Silva, E., Lopez-Alarcon, C. & Davies, M. J., 1 Nov 2019, In: Free Radical Biology and Medicine. 143, p. 375-386Research output: Contribution to journal › Journal article › Research › peer-review
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Copper ion / H2O2 oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action
Tiwari, M. K., Hägglund, P. M., Møller, I. M., Davies, M. J. & Bjerrum, M. J., Sept 2019, In: Redox Biology. 26, 15 p., 101262.Research output: Contribution to journal › Journal article › Research › peer-review
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Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients
Sharma, M., Danigaard, D., Senolt, L., Svensson, B., Bay-Jensen, A.-C., Nielsen, C. H. & Hägglund, P., 30 Sept 2019, In: Journal of Proteomics. 208, 103484.Research output: Contribution to journal › Journal article › Research › peer-review
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Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]
Shu, N., Hagglund, P. M. & Davies, M., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.Research output: Contribution to journal › Conference article › Research
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Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo
Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Karsdal, M. A., Mobasheri, A., Hagglund, P., Bay-Jensen, A.-C. & Thudium, C. S., Jul 2019, In: Biochemical Pharmacology. 165, p. 91-98Research output: Contribution to journal › Journal article › Research › peer-review
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Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function
Degendorfer, G., Chuang, C. Y., Mariotti, M., Hammer, A., Hoefler, G., Hägglund, P., Malle, E., Wise, S. G. & Davies, M. J., 1 Feb 2018, In: Free Radical Biology & Medicine. 115, S1, p. 202-214 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of protein cross-links induced by oxidative reactions
Hagglund, P., Mariotti, M. & Davies, M. J., 3 Aug 2018, In: Expert Review of Proteomics. 15, 8, p. 665-681Research output: Contribution to journal › Review › peer-review
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Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation
Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, M. J. & Hagglund, P., 1 Jun 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027Research output: Contribution to journal › Journal article › Research › peer-review