Olivier Thierry Taboureau

Research output

Research output per year 2008 2013 2016 2017 2018 2019 2019

• 14 Journal article
• 1 Comment/debate
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1

  Briand, E., Thomsen, R., Linnet, K., Rasmussen, H. B., Brunak, S. & Taboureau, O., 29 Jul 2019, In: Molecules. 24, 15, 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human CES1 protein 100%
  • Carboxylesterase 70%
  • machine learning 66%
  • Machine Learning 59%
  • drugs 52%
  1 Citation (Scopus)

  26 Downloads (Pure)

• sAOP: linking chemical stressors to adverse outcomes pathway networks

  Aguayo-Orozco, A., Audouze, K., Siggaard, T., Barouki, R., Brunak, S. & Taboureau, O., 15 Dec 2019, In: Bioinformatics. 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adverse Outcome Pathways 100%
  • Pathway 71%
  • Linking 63%
  • Toxicological Phenomena 29%
  • Wikis 22%
  5 Citations (Scopus)

  4 Downloads (Pure)

• The use of systems biology in chemical risk assessment

  Aguayo-Orozco, A., Taboureau, O. & Brunak, S., 2019, In: Current Opinion in Toxicology. 15, p. 48-54 7 p.

  Research output: Contribution to journal › Review › peer-review

  • Risk Assessment 100%
  • Systems Biology 98%
  • Adverse Outcome Pathways 68%
  • Toxicology 60%
  • Pharmacologic Actions 29%
  4 Citations (Scopus)

  16 Downloads (Pure)
• 2018

  Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

  Aguayo-Orozco, A., Bois, F. Y., Brunak, S. & Taboureau, O., 2018, In: Frontiers in Genetics. 9, p. 1-15 396.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fatty Liver 100%
  • Gene Expression 84%
  • Adverse Outcome Pathways 77%
  • linolenic acid drug combination linoleic acid 77%
  • Liver 72%
  5 Citations (Scopus)

  101 Downloads (Pure)

• Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

  Grinberg, M., Stöber, R. M., Albrecht, W., Edlund, K., Schug, M., Godoy, P., Cadenas, C., Marchan, R., Lampen, A., Braeuning, A., Buhrke, T., Leist, M., Oberemm, A., Hellwig, B., Kamp, H., Gardner, I., Escher, S., Taboureau, O., Aguayo-Orozco, A., Sachinidis, A., & 3 othersEllinger-Ziegelbauer, H., Rahnenführer, J. & Hengstler, J. G., Dec 2018, In: Archives of Toxicology. 92, 12, p. 3517-3533 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Toxicogenetics 100%
  • Valproic Acid 96%
  • Directories 93%
  • Microarrays 71%
  • Hepatocytes 55%
  24 Citations (Scopus)
• 2017

  Adverse outcome pathways: opportunities, limitations and open questions

  Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D., & 33 othersHöhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G., 1 Nov 2017, In: Archives of Toxicology. 91, 11, p. 3477-3505 29 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adverse Outcome Pathways 100%
  • Toxicokinetics 86%
  • Plastic Property 69%
  • Pharmacological Metabolism 46%
  • Strength 38%
  153 Citations (Scopus)

• Human Environmental Disease Network: A computational model to assess toxicology of contaminants

  Taboureau, O. & Audouze, K., 2017, In: Altex. 17, 2, p. 289-300

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Toxicology 100%
  • Animal Testing Alternatives 10%
  • Chlordan 10%
  • bisphenol A 7%
  • Systems Biology 7%
  14 Citations (Scopus)

  56 Downloads (Pure)

• Nomenclature for alleles of the human carboxylesterase 1 gene

  INDICES Consortium, 1 Jan 2017, In: Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  4 Citations (Scopus)
• 2016

  ChemProt-3.0: a global chemical biology diseases mapping

  Kringelum, J. V., Kjærulff, S. K., Brunak, S., Lund, O., Oprea, T. I. & Taboureau, O. T., 2016, In: Database: The Journal of Biological Databases and Curation. 2016, 7 p., bav123.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteins 100%
  • Biological Sciences 79%
  • Pharmacology 72%
  • Quantitative Structure-Activity Relationship 50%
  • Pharmacogenomic Testing 48%
  45 Citations (Scopus)

  131 Downloads (Pure)

• In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

  Orozco, A. A., Audouze, K., Brunak, S. & Taboureau, O., 1 Dec 2016, In: Current Pharmaceutical Design. 22, 46, p. 6895-6902 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Computer Simulation 100%
  • Therapeutic Uses 87%
  • Toxic 79%
  • Poisons 78%
  • Pharmacology 70%
  2 Citations (Scopus)

  47 Downloads (Pure)

• Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches

  Nzabonimpa, G. S., Rasmussen, H. B., Brunak, S., Taboureau, O. & INDICES Consortium, 1 Jun 2016, In: Drug Metabolism and Personalized Therapy. 31, 2, p. 97-106 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human CES1 protein 100%
  • Missense Mutation 54%
  • Computer Simulation 49%
  • Single Nucleotide Polymorphism 43%
  • Carboxylic Ester Hydrolases 34%
  3 Citations (Scopus)
• 2014

  Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

  Hansen, M. R., Le Quement, S. T., Jakobsen, T. H., Skovstrup, S., Taboureau, O., Tolker-Nielsen, T., Givskov, M. & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • L-Homoserine Lactone 100%
  • homoserine lactone 82%
  • Solid-Phase Synthesis Techniques 80%
  • Quorum Sensing 63%
  • Signalling Molecule 63%
  5 Citations (Scopus)
• 2013

  Identification of LasR ligands through a virtual screening approach

  Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, T. H., Harmsen, M., Tolker-Nielsen, T., Nielsen, T. E., Givskov, M. & Taboureau, O., Jan 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(3-Oxododecanoyl)-L-Homoserine Lactone 100%
  • N-(3-oxododecanoyl)homoserine lactone 86%
  • Bacterial Drug Resistance 70%
  • Ligands 69%
  • Antimicrobial Agent 68%
  14 Citations (Scopus)

• Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: Considerations for epidemiological studies

  Frederiksen, H., Kranich, S. K., Jørgensen, N., Taboureau, O., Petersen, J. H. & Andersson, A. M., 15 Jan 2013, In: Environmental Science & Technology. 47, 2, p. 958-967 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • phthalate 100%
  • Phthalate 95%
  • excretion 91%
  • urine 88%
  • metabolite 77%
  84 Citations (Scopus)
• 2011

  ChemProt: a disease chemical biology database

  Taboureau, O., Nielsen, S. K., Audouze, K. M. L., Weinhold, N., Edsgärd, D., Roque, F. S., Kouskoumvekaki, I., Bora, A., Curpan, R., Jensen, T. S., Brunak, S. & Oprea, T., Jan 2011, In: Nucleic Acids Research. 39, Database issue, p. D367-72

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemical Databases 100%
  • Proteins 24%
  • Protein Interaction Maps 23%
  • Molecular Sequence Annotation 12%
  • bisphenol A 12%
  65 Citations (Scopus)
• 2008

  hERG classification model based on a combination of support vector machine method and GRIND descriptors

  Li, Q., Jørgensen, F. S., Oprea, T., Brunak, S. & Taboureau, O., Jan 2008, In: Molecular Pharmaceutics. 5, 1, p. 117-127 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Support Vector Machine 100%
  • Ether 91%
  • QT Interval 79%
  • Classifier 55%
  • Drug 43%
  65 Citations (Scopus)