Morten Heiberg Bestle

Research output

Research output per year 1999 2017 2018 2019 2019

• 41 Journal article
• 3 Review
• 1 Comment/debate
• 1 Conference abstract in journal
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  Agents intervening against delirium in the intensive care unit (AID-ICU) - Protocol for a randomised placebo-controlled trial of haloperidol in patients with delirium in the ICU

  Andersen-Ranberg, N. C., Poulsen, L. M., Perner, A., Wetterslev, J., Estrup, S., Lange, T., Ebdrup, B. H., Hästbacka, J., Morgan, M. P. G., Citerio, G., Zafrani, L., Caballero, J., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M., Pedersen, H. B. S., Hildebrandt, T., Thee, C., Jensen, T. B., & 3 othersDey, N., Nielsen, L. G. & Mathiesen, O., 1 Nov 2019, In: Acta Anaesthesiologica Scandinavica. 63, 10, p. 1426-1433 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Delirium 100%
  • Haloperidol 95%
  • Intensive Care Units 72%
  • Placebos 60%
  • Randomized Controlled Trials 58%
  3 Citations (Scopus)

• Co-administration of iloprost and eptifibatide in septic shock (CO-ILEPSS): A randomised, controlled, double-blind investigator-initiated trial investigating safety and efficacyA randomised, controlled, double-blind investigator-initiated trial investigating safety and efficacy

  Berthelsen, R. E., Ostrowski, S. R., Bestle, M. H. & Johansson, P. I., 2019, In: Critical Care. 23, 10 p., 301.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Eptifibatide 100%
  • Iloprost 91%
  • Septic Shock 66%
  • Research Personnel 45%
  • Safety 37%
  3 Citations (Scopus)

• Conservative versus Liberal fluid therapy in Septic Shock (CLASSIC) trial - protocol and statistical analysis plan

  Meyhoff, T. S., Hjortrup, P. B., Møller, M. H., Wetterslev, J., Lange, T., Kjær, M-B. N., Jonsson, A. B., Hjortsø, C. J. S., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I., Ostermann, M., Mouncey, P., Rowan, K., Cecconi, M., Ferrer, R., Malbrain, M. L. N. G., & 11 othersAhlstedt, C., Hoffmann, S., Bestle, M. H., Nebrich, L., Russell, L., Vang, M., Rasmussen, M. L., Sølling, C., Rasmussen, B. S., Brøchner, A. C. & Perner, A., 1 Oct 2019, In: Acta Anaesthesiologica Scandinavica. 63, 9, p. 1262-1271 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fluid Therapy 100%
  • Septic Shock 87%
  • Intensive Care Units 28%
  • boldenone undecylenate 25%
  • Mortality 17%
  7 Citations (Scopus)

• Long-term mortality in the European, randomised SUP-ICU trial

  Marker, S., Krag, M., Perner, A., Wetterslev, J., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Rasmussen, B. S., Elkmann, T., Bestle, M., Arenkiel, B., Laake, J. H., Kamper, M. K., Lang, M., Pawlowicz-Dworzanska, M. B., Karlsson, S., & 5 othersLiisanantti, J., Dey, N., Knudsen, H., Granholm, A. & Møller, M. H., 2019, In: Acta Anaesthesiologica Scandinavica. 63, 8, p. 14 1 p., ABSSUB-223.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  7 Citations (Scopus)

  12 Downloads (Pure)

• Low Incidence of Biphasic Allergic Reactions in Patients Admitted to Intensive Care after Anaphylaxis

  Højlund, S., Søe-Jensen, P., Perner, A., Bestle, M. H., Carl, P., Thormar, K., Viggers, S., Elberling, S. & Garvey, L. H., 1 Feb 2019, In: Anesthesiology. 130, 2, p. 284-291 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Anaphylaxis 100%
  • Critical Care 80%
  • Hypersensitivity 75%
  • Incidence 44%
  • Intensive Care Units 38%
  2 Citations (Scopus)

• Mortality in critical illness: The impact of asymmetric dimethylarginine on survival—A systematic review and meta-analysis

  Mortensen, K. M., Itenov, T. S., Hansen, M. B., Hvid, K., Lundstrøm, L. H. & Bestle, M. H., 2019, In: Acta Anaesthesiologica Scandinavica. 63, 6, p. 708-719

  Research output: Contribution to journal › Review › peer-review

  • N,N-dimethylarginine 100%
  • Critical Illness 67%
  • Meta-Analysis 53%
  • Systematic Reviews 53%
  • Mortality 36%
  1 Citation (Scopus)

• Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial

  Marker, S., Krag, M., Perner, A., Wetterslev, J., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Rasmussen, B. S., Elkmann, T., Bestle, M., Arenkiel, B., Laake, J. H., Kamper, M. K., Lång, M., Pawlowicz-Dworzanska, M. B., Karlsson, S., & 5 othersLiisanantti, J., Dey, N., Knudsen, H., Granholm, A. & Møller, M. H., 1 Oct 2019, In: Acta Anaesthesiologica Scandinavica. 63, 9, p. 1184-1190 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pantoprazole 100%
  • Ulcer 62%
  • Intensive Care Units 57%
  • Hemorrhage 44%
  • Mortality 34%
  2 Citations (Scopus)
• 2018

  Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

  on behalf of the ICON and SOAP investigators & SOAP investigators, 2018, In: Intensive Care Medicine. 44, 3, p. 337-344 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Care 100%
  • Intensive Care Units 94%
  • Sepsis 91%
  • Multilevel Analysis 17%
  • Mortality 6%
  57 Citations (Scopus)

  30 Downloads (Pure)

• Duration of acute kidney injury in critically ill patients

  Federspiel, C. K., Itenov, T. S., Mehta, K., Hsu, R. K., Bestle, M. H. & Liu, K. D., 1 Dec 2018, In: Annals of Intensive Care. 8, 1, p. 1-9 30.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Kidney Injury 100%
  • Critical Illness 97%
  • National Heart, Lung, and Blood Institute (U.S.) 6%
  • Oliguria 6%
  • Adult Respiratory Distress Syndrome 5%
  17 Citations (Scopus)

  31 Downloads (Pure)

• Fluid accumulation during acute kidney injury in the intensive care unit

  Berthelsen, R. E., Perner, A., Jensen, A. K., Jensen, J-U. & Bestle, M. H., Jul 2018, In: Acta Anaesthesiologica Scandinavica. 62, 6, p. 780-790

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Kidney Injury 100%
  • Intensive Care Units 87%
  • Water-Electrolyte Balance 64%
  • Kidney 28%
  • Joints 27%
  4 Citations (Scopus)

• Forced fluid removal in intensive care patients with acute kidney injury: The randomised FFAKI feasibility trial

  Berthelsen, R. E., Perner, A., Jensen, A. K., Rasmussen, B. S., Jensen, J. U., Wiis, J., Behzadi, M. T. & Bestle, M. H., Aug 2018, In: Acta Anaesthesiologica Scandinavica. 62, 7, p. 936-944

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Kidney Injury 100%
  • Critical Care 92%
  • Intensive Care Units 87%
  • Water-Electrolyte Balance 77%
  • Ideal Body Weight 54%
  11 Citations (Scopus)

• Hypophosphatemia and duration of respiratory failure and mortality in critically ill patients

  Federspiel, C. K., Itenov, T. S., Thormar, K., Liu, K. D. & Bestle, M. H., Sept 2018, In: Acta Anaesthesiologica Scandinavica. 62, 8, p. 1098-1104

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hypophosphatemia 100%
  • Respiratory Insufficiency 69%
  • Critical Illness 68%
  • Mortality 37%
  • Phosphates 36%
  7 Citations (Scopus)

• Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

  Itenov, T. S., Johansen, M. E., Bestle, M., Thormar, K., Hein, L., Gyldensted, L., Lindhardt, A., Christensen, H., Estrup, S., Pedersen, H. P., Harmon, M., Soni, U. K., Perez-Protto, S., Wesche, N., Skram, U., Petersen, J. A., Mohr, T., Waldau, T., Poulsen, L. M., Strange, D., & 9 othersJuffermans, N. P., Sessler, D. I., Tønnesen, E., Møller, K., Kristensen, D. K., Cozzi-Lepri, A., Lundgren, J. D., Jensen, J-U. & Cooling and Surviving Septic Shock (CASS) Trial Collaboration, 1 Mar 2018, In: The Lancet Respiratory Medicine. 6, 3, p. 183-192

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 6-chloropenicillanic acid S-sulfoxide 100%
  • Induced Hypothermia 64%
  • Septic Shock 53%
  • Respiratory Insufficiency 49%
  • Mortality 16%
  22 Citations (Scopus)

• Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients

  Schjørring, O. L., Toft-Petersen, A. P., Kusk, K. H., Mouncey, P., Sørensen, E. E., Berezowicz, P., Bestle, M. H., Bülow, H-H., Bundgaard, H., Christensen, S., Iversen, S. A., Kirkeby-Garstad, I., Krarup, K. B., Kruse, M., Laake, J. H., Liboriussen, L., Laebel, R. L., Okkonen, M., Poulsen, L. M., Russell, L., & 8 othersSjövall, F., Sunde, K., Søreide, E., Waldau, T., Walli, A. R., Perner, A., Wetterslev, J. & Rasmussen, B. S., Nov 2018, In: Acta Anaesthesiologica Scandinavica. 62, 10, p. 1443-1451

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Care 100%
  • Intensive Care Units 94%
  • Arterial Pressure 92%
  • Oxygen 81%
  • Clinical Trials 21%
  10 Citations (Scopus)

• Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

  Krag, M., Marker, S., Perner, A., Wetterslev, J., Wise, M. P., Schefold, J. C., Keus, F., Guttormsen, A. B., Bendel, S., Borthwick, M., Lange, T., Rasmussen, B. S., Siegemund, M., Bundgaard, H., Elkmann, T., Jensen, J. V., Nielsen, R. D., Liboriussen, L., Bestle, M. H., Elkjær, J. M., & 47 othersPalmqvist, D. F., Backlund, M., Laake, J. H., Badstolokken, P. M., Gronlund, J., Breum, O., Walli, A., Winding, R., Iversen, S., Jarnvig, I. -L., White, J. O., Brand, B., Madsen, M. B., Quist, L., Thornberg, K. J., Møller, A., Wiis, J., Granholm, A., Anthon, C. T., Meyhoff, T. S., Hjortrup, P. B., Aagaard, S. R., Andreasen, J. B., Sorensen, C. A., Haure, P., Hauge, J., Hollinger, A., Scheuzger, J., Tuchscherer, D., Vuilliomenet, T., Takala, J., Jakob, S. M., Vang, M. L., Paelestik, K. B., Andersen, K. L. D., van der Horst, I. C. C., Dieperink, W., Fjolner, J., Kjer, C. K. W., Solling, C., Solling, C. G., Karttunen, J., Morgan, M. P. G., Sjobo, B., Engstrom, J., Agerholm-Larsen, B. & Møller, M. H., 6 Dec 2018, In: New England Journal of Medicine. 379, 23, p. 2199-2208 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pantoprazole 100%
  • Intensive Care Units 57%
  • Hemorrhage 44%
  • Placebos 35%
  • Clostridium Infections 10%
  110 Citations (Scopus)

• Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model

  Itenov, T. S., Berthelsen, R. E., Jensen, J-U., Gerds, T. A., Pedersen, L. M., Strange, D., Thormar, K., Loken, J., Andersen, M. H., Tousi, H., Reiter, N., Lundgren, J. D. & Bestle, M. H., 1 Mar 2018, In: Critical Care and Resuscitation. 20, 1, p. 54-60 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Kidney Injury 100%
  • Critical Illness 97%
  • Intensive Care Units 32%
  • Kidney 28%
  • Denmark 27%
  6 Citations (Scopus)

• Recovery programme for ICU survivors has no effect on relatives’ quality of life: Secondary analysis of the RAPIT-study

  Bohart, S., Egerod, I., Bestle, M. H., Overgaard, D., Christensen, D. F. & Jensen, J. F., 2018, In: Intensive and Critical Care Nursing. 47, p. 39-45 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Survivors 100%
  • Quality of Life 73%
  • Critical Care 66%
  • Anxiety 27%
  • Sense of Coherence 26%
  8 Citations (Scopus)
• 2017

  Behandling af hypertermi

  Translated title of the contribution: Treatment of hyperthermiaMørch, S. S., Andersen, J. D. H. & Bestle, M. H., 2017, In: Ugeskrift for Laeger. 179, 30, 5 p., V06160461.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Serotonin Syndrome 100%
  • Fever 98%
  • Heat Stroke 96%
  • Malignant Hyperthermia 89%
  • Ice 79%

• Effects of fluid restriction on measures of circulatory efficacy in adults with septic shock

  Hjortrup, P. B., Haase, N., Wetterslev, J., Lange, T., Bundgaard, H., Rasmussen, B. S., Dey, N., Wilkman, E., Christensen, L., Lodahl, D., Bestle, M. & Perner, A., 1 Apr 2017, In: Acta Anaesthesiologica Scandinavica. 61, 4, p. 390–398 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Septic Shock 100%
  • Resuscitation 93%
  • Random Allocation 40%
  • Lactic Acid 24%
  • Norepinephrine 23%
  11 Citations (Scopus)

• Endothelial Damage Signals Refractory Acute Kidney Injury in Critically Ill Patients

  Itenov, T. S., Jensen, J-U., Ostrowski, S. R., Johansson, P. I., Thormar, K. M., Lundgren, J. D., Bestle, M. H. & “Procalcitonin And Survival Study” study group, 1 Jun 2017, In: Shock. 47, 6, p. 696-701

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Kidney Injury 100%
  • Critical Illness 97%
  • Thrombomodulin 59%
  • Procalcitonin 57%
  • Kidney 48%
  7 Citations (Scopus)

• Forced fluid removal versus usual care in intensive care patients with high-risk acute kidney injury and severe fluid overload (FFAKI): study protocol for a randomised controlled pilot trial

  Berthelsen, R. E., Itenov, T., Perner, A., Jensen, J. U., Ibsen, M., Kryger Jensen, A. E. & Bestle, M., 2017, In: Trials. 18, 8 p., 189.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Water-Electrolyte Balance 100%
  • Acute Kidney Injury 90%
  • Critical Care 83%
  • Randomized Controlled Trials 64%
  • Ethics Committees 16%
  1 Citation (Scopus)

  70 Downloads (Pure)

• Heat Stroke: A Medical Emergency Appearing in New Regions

  Mørch, S. S., Andersen, J. D. H. & Bestle, M. H., 2017, In: Case Reports in Critical Care. 2017, 3 p., 6219236.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Heat Stroke 100%
  • Infrared Rays 53%
  • Emergencies 52%
  • Global Warming 27%
  • Climate 19%
  59 Downloads (Pure)

• Nitrogenoxid og sepsis

  Translated title of the contribution: Nitric oxide and sepsisEl-Haj, L. & Bestle, M. H., 2017, In: Ugeskrift for Laeger. 179, 3 p., V01170086.

  Research output: Contribution to journal › Review › peer-review

  • Nitric Oxide 100%
  • Sepsis 99%
  • Septic Shock 76%
  • Oxides 29%
  • Human Body 23%
  2 Citations (Scopus)

• Risk prediction models for mortality in patients with ventilator-associated pneumonia: A systematic review and meta-analysis

  Larsson, J. E., Itenov, T. S. & Bestle, M. H., 1 Feb 2017, In: Journal of Critical Care. 37, p. 112-118 7 p.

  Research output: Contribution to journal › Review › peer-review

  • Ventilator-Associated Pneumonia 100%
  • Meta-Analysis 58%
  • Systematic Reviews 57%
  • APACHE 39%
  • Mortality 39%
  15 Citations (Scopus)

• Self-Rated Health as a Predictor of Death after Two Years: The Importance of Physical and Mental Wellbeing Postintensive Care

  Vejen, M., Bjorner, J. B., Bestle, M. H., Lindhardt, A. & Jensen, J. U., 21 Aug 2017, In: Journal of Biomedicine and Biotechnology. 2017, (2017), p. 1-9 9 p., 5192640.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Confidence Intervals 100%
  • Health 81%
  • Critical Care 73%
  • Survivors 73%
  • Mortality 63%
  4 Citations (Scopus)

  46 Downloads (Pure)

• Succesfuld behandling af svær dabigatranoverdosering med idarucizumab hos en patient med nyresvigt

  Translated title of the contribution: Successful treatment of severe dabigatran intoxication with idarucizumab in a patient with acute kidney injuryPoulsen, C. G., Bestle, M. & Boesby, L., 1 Mar 2017, In: Ugeskrift for Laeger. 179, 7, 3 p., V08160562.

  Research output: Contribution to journal › Letter › peer-review

  • idarucizumab 100%
  • Dabigatran 76%
  • Acute Kidney Injury 55%
  • prothrombin complex concentrates 27%
  • Tranexamic Acid 25%

• Towards a new orientation: a qualitative longitudinal study of an intensive care recovery programme

  Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F. & Egerod, I., 1 Jan 2017, In: Journal of Clinical Nursing. 26, 1-2, p. 77-90

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Care 100%
  • Longitudinal Studies 94%
  • Referral and Consultation 71%
  • Intensive Care Units 27%
  • Psychology 22%
  7 Citations (Scopus)

• Unique Uses of Cooling Strategies

  Rincon, F., Bestle, M., Brossner, G. & Vanderpol, J., 1 Sept 2017, In: Therapeutic Hypothermia and Temperature Management. 7, 3, p. 118-121 4 p.

  Research output: Contribution to journal › Comment/debate › Research
• 2016

  A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: a multicenter randomized controlled trial, the RAPIT study

  Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D., Elklit, A., Hansen, R. L., Knudsen, H., Grode, L. B. & Overgaard, D., 1 Nov 2016, In: Intensive Care Medicine. 42, 11, p. 1733-1743 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sense of Coherence 100%
  • Survivors 62%
  • Intensive Care Units 58%
  • Psychology 48%
  • Randomized Controlled Trials 47%
  49 Citations (Scopus)

• High Levels of Methylarginines Were Associated With Increased Mortality in Patients With Severe Sepsis

  Mortensen, K. M., Itenov, T. S., Haase, N., Müller, R. B., Ostrowski, S. R., Johansson, P. I., Olsen, N. V., Perner, A., Søe-Jensen, P. & Bestle, M. H., Oct 2016, In: Shock. 46, 4, p. 365-372 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • dimethylarginine 100%
  • symmetric dimethylarginine 60%
  • Sepsis 49%
  • Mortality 30%
  • Septic Shock 25%
  13 Citations (Scopus)

• Hyaluronic Acid Assays: Turbidimetric or Enzyme-Based Immune Assay? A Method Comparison Study

  Itenov, T. S., Kirkby, N. S., Bestle, M. H., Nilsson, A. C., Erlandsen, E. J., Peters, L. & Jensen, J-U., 1 Sept 2016, In: Journal of Clinical Laboratory Analysis. 30, 5, p. 524–528 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hyaluronic Acid 100%
  • Immunoturbidimetry 63%
  • Enzymes 47%
  • Immunoassay 41%
  • biochemistry 34%
  3 Citations (Scopus)

• Meralgia Paresthetica after Prone Positioning Ventilation in the Intensive Care Unit

  Juhl, C. S., Ballegaard, M., Bestle, M. H. & Tfelt-Hansen, P., 2016, In: Case Reports in Critical Care. 2016, 3 p., 7263201.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Femoral Neuropathy 100%
  • Ventilation 54%
  • Intensive Care Units 51%
  • Prone Position 38%
  • Artificial Respiration 29%
• 2015

  Begrænset evidens for monitorering og behandling af fosfatmangel hos kritisk syge patienter

  Translated title of the contribution: Limited evidence for monitoring and treatment of hypophosphataemia in critically ill patientsFederspiel, C., Itenov, T. S., Thormar, K. & Bestle, M. H., 7 Dec 2015, In: Ugeskrift for Laeger. 177, 50, p. 2-6 5 p., V07150610.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Illness 100%
  • Phosphates 46%
  • Intensive Care Units 44%
  • Randomized Controlled Trials 36%
  • Mortality 27%
  1 Citation (Scopus)

• Impact of follow-up consultations for ICU survivors on post-ICU syndrome: a systematic review and meta-analysis

  Jensen, J. F., Thomsen, T., Overgaard, D., Bestle, M. H., Christensen, D. & Egerod, I., 1 May 2015, In: Intensive Care Medicine. 41, 5, p. 763-75 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Survivors 100%
  • Intensive Care Units 94%
  • Meta-Analysis 85%
  • Systematic Reviews 84%
  • Referral and Consultation 84%
  75 Citations (Scopus)

• Invasive Candida Infections and the Harm From Antibacterial Drugs in Critically Ill Patients: Data From a Randomized, Controlled Trial to Determine the Role of Ciprofloxacin, Piperacillin-Tazobactam, Meropenem, and Cefuroxime

  Jensen, J. U. S., Hein, L., Lundgren, B., Bestle, M. H., Mohr, T., Andersen, M. H., Løken, J., Tousi, H., Søe-Jensen, P., Lauritsen, A. Ø., Strange, D., Petersen, J. A., Thormar, K., Larsen, K. M., Drenck, N. E., Helweg-Larsen, J., Johansen, M. E., Reinholdt, K., Møller, J. K., Olesen, B., & 6 othersArendrup, M. C., Østergaard, C., Cozzi-Lepri, A., Grarup, J., Lundgren, J. D. & Procalcitonin and Survival Study Group, 4 Mar 2015, In: Critical Care Medicine. 43, 3, p. 594-602 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cefuroxime 100%
  • Tazobactam Drug Combination Piperacillin 99%
  • Meropenem 92%
  • Ciprofloxacin 78%
  • Candida 77%
  23 Citations (Scopus)

• Mild induced hypothermia: Effects on sepsis-related coagulopathy -results from a randomized controlled trial

  Johansen, M. E., Jensen, J. U. S., Bestle, M. H., Ostrowski, S. R., Thormar, K., Christensen, H., Pedersen, H. P., Poulsen, L., Mohr, T., Kjær, J., Cozzi-Lepri, A., Møller, K., Tønnesen, E., Lundgren, J. D. & Johansson, P. I., 1 Jan 2015, In: Thrombosis Research. 135, 1, p. 175-182 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Induced Hypothermia 100%
  • Sepsis 65%
  • Randomized Controlled Trials 54%
  • Thrombelastography 46%
  • Hypothermia 36%
  12 Citations (Scopus)

• Profound Endothelial Damage Predicts Impending Organ Failure and Death in Sepsis

  Johansen, M. E., Johansson, P. I., Ostrowski, S. R., Bestle, M. H., Hein, L., Jensen, A. L. G., Søe-Jensen, P., Andersen, M. H., Steensen, M., Mohr, T., Thormar, K., Lundgren, B., Cozzi-Lepri, A., Lundgren, J. D. & Jensen, J-U., 1 Feb 2015, In: Seminars in Thrombosis and Hemostasis. 41, 1, p. 16-25 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sepsis 100%
  • Thrombomodulin 81%
  • Syndecan-1 60%
  • Proportional Hazards Models 36%
  • Endothelium 36%
  53 Citations (Scopus)
• 2014

  Red blood cell transfusion in septic shock: clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort

  Rosland, R. G., Hagen, M. U., Haase, N., Holst, L. B., Plambech, M., Madsen, K. R., Søe-Jensen, P., Poulsen, L. M., Bestle, M. & Perner, A., 27 Feb 2014, In: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 22, p. 14

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Erythrocyte Transfusion 100%
  • Septic Shock 83%
  • Hemoglobins 32%
  • Simplified Acute Physiology Score 28%
  • Organ Dysfunction Scores 27%
  28 Citations (Scopus)

  54 Downloads (Pure)

• Serum and Plasma Neutrophil Gelatinase Associated Lipocalin (NGAL) Levels are Not Equivalent in Patients Admitted to Intensive Care

  Itenov, T. S., Bangert, K., Christensen, P. H., Jensen, J-U., Bestle, M. H. & Procalcitonin and Survival Study (PASS)-study group, Mar 2014, In: Journal of Clinical Laboratory Analysis. 28, 2, p. 163-167 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipocalin-2 100%
  • Critical Care 65%
  • confidence 56%
  • Edetic Acid 55%
  • Plasma 46%
  7 Citations (Scopus)
• 2013

  Effect of intermediate care on mortality following emergency abdominal surgery. The InCare trial: study protocol, rationale and feasibility of a randomised multicentre trial

  Vester-Andersen, M., Waldau, T., Wetterslev, J., Møller, M. H., Rosenberg, J., Jørgensen, L. N., Gillesberg, I. E., Jakobsen, H. L., Hansen, E. G., Poulsen, L. M., Skovdal, J., Søgaard, E. K., Bestle, M. H., Vilandt, J., Rosenberg, I., Berthelsen, R. E., Pedersen, J. H., Madsen, M. R., Feurstein, T., Busse, M. J., & 7 othersAndersen, J., Maschmann, C., Rasmussen, M., Jessen, C. M., Bugge, L., Ording, H. & Møller, A., 2 Feb 2013, In: Trials. 14, 1, p. 37

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multicenter Studies 100%
  • Emergencies 88%
  • Mortality 57%
  • Postoperative Care 53%
  • APACHE 27%
  11 Citations (Scopus)

• The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial

  Johansen, M. E., Jensen, J. U. S., Bestle, M. H., Hein, L., Lauritsen, A. Ø., Tousi, H., Larsen, K. M., Løken, J., Mohr, T., Thormar, K., Johansson, P. I., Cozzi-Lepri, A. & Lundgren, J. D., 28 Nov 2013, In: PloS one. 8, 11, p. e81477

  Research output: Contribution to journal › Journal article › Research

  • Randomized Controlled Trial 100%
  • thrombocytopenia 93%
  • Platelets 87%
  • Thrombocytopenia 63%
  • Critical Illness 62%
  13 Citations (Scopus)
• 2012

  Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial

  Jensen, J-U. S., Hein, L., Lundgren, B., Bestle, M. H., Mohr, T., Andersen, M. H., Thornberg, K. J., Løken, J., Steensen, M., Fox, Z., Tousi, H., Søe-Jensen, P., Lauritsen, A. Ø., Strange, D. G., Reiter, N., Thormar, K., Fjeldborg, P. C., Larsen, K. M., Drenck, N-E., Johansen, M. E., & 6 othersNielsen, L. R., Ostergaard, C., Kjær, J., Grarup, J., Lundgren, J. D. & Procalcitonin And Survival Study (PASS) Group, 2012, In: B M J Open. 2, 2, p. e000635

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Critical Illness 100%
  • Renal Insufficiency 94%
  • Tazobactam Drug Combination Piperacillin 84%
  • Glomerular Filtration Rate 81%
  • Anti-Bacterial Agents 70%
  52 Citations (Scopus)

• Refinement of prompts for rapid response teams*

  Jensen, J-U., Bestle, M. & Lundgren, J., Jul 2012, In: The Open Critical Care Medicine Journal. 40, 7, p. 2241-2 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2011

  Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial

  Jensen, J. U., Hein, L., Lundgren, B., Bestle, M. H., Mohr, T. T., Andersen, M. H., Thornberg, K. J., Løken, J., Steensen, M., Fox, Z., Tousi, H., Søe-Jensen, P., Lauritsen, A. Ø., Strange, D., Petersen, P. L., Reiter, N., Hestad, S., Thormar, K., Fjeldborg, P., Larsen, K. M., & 6 othersDrenck, N. E., Ostergaard, C., Kjær, J., Grarup, J., Lundgren, J. D. & Procalcitonin And Survival Study (PASS) Group, 1 Sept 2011, In: Critical Care Medicine. 39, 9, p. 2048-58 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Procalcitonin 100%
  • Intensive Care Units 64%
  • Anti-Bacterial Agents 51%
  • Survival 43%
  • Infections 37%
  271 Citations (Scopus)
• 2002

  Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

  Bestle, M. H., Olsen, N. V., Poulsen, T. D., Roach, R., Fogh-Andersen, N. & Bie, P., 2002, In: Journal of Applied Physiology. 92, 5, p. 1911-22 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vasopressins 100%
  • Hypoxia 75%
  • Ularitide 67%
  • Kidney 51%
  • Oceans and Seas 43%
  29 Citations (Scopus)
• 1999

  Blood pressure and plasma catecholamines in acute and prolonged hypoxia: effects of local hypothermia

  Kanstrup, I. L., Poulsen, T. D., Hansen, J. M., Andersen, L. J., Bestle, M. H., Christensen, N. J. & Olsen, N. V., Dec 1999, In: Journal of Applied Physiology. 87, 6, p. 2053-8 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hypothermia 100%
  • Catecholamines 89%
  • Hypoxia 75%
  • Oceans and Seas 73%
  • Blood Pressure 60%
  56 Citations (Scopus)

• Cardiovascular, endocrine, and renal effects of urodilatin in normal humans

  Bestle, M. H., Olsen, N. V., Christensen, P., Jensen, B. V. & Bie, P., Mar 1999, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 276, 3 Pt 2, p. R684-95

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ularitide 100%
  • Cardiac Output 35%
  • Stroke Volume 34%
  • Arterial Pressure 30%
  • Kidney 30%
  32 Citations (Scopus)