Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

Morten H Bestle; Niels Vidiendal Olsen; Troels D Poulsen; Robert Roach; Niels Fogh-Andersen; Peter Bie

doi:10.1152/japplphysiol.00936.2001

Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

Morten H Bestle, Niels Vidiendal Olsen, Troels D Poulsen, Robert Roach, Niels Fogh-Andersen, Peter Bie

Eyepath Lab

29 Citations (Scopus)

Abstract

Effects of hypobaric hypoxemia on endocrine and renal parameters of body fluid homeostasis were investigated in eight normal men during a sojourn of 8 days at an altitude of 4,559 m. Endocrine and renal responses to an osmotic stimulus (5% hypertonic saline, 3.6 ml/kg over 1 h) were investigated at sea level and on day 6 at altitude. Several days of hypobaric hypoxemia reduced body weight (-2.1 +/- 0.4 kg), increased plasma osmolality (+5.3 +/- 1.4 mosmol/kgH(2)O), elevated blood pressure (+12 +/- 1 mmHg), reduced creatinine clearance (122 +/- 6 to 96 +/- 10 ml/min), inhibited the renin system (19.5 +/- 2.0 to 10.9 +/- 0.9 mU/l) and plasma vasopressin (1.14 +/- 0.16 to 0.38 +/- 0.06 pg/ml), and doubled circulating levels of norepinephrine (103 +/- 16 to 191 +/- 35 pg/ml) and endothelin-1 (3.0 +/- 0.2 to 6.3 +/- 0.6 pg/ml), whereas urodilatin excretion rate decreased from day 2 (all changes P <0.05 compared with sea level). Plasma arginine vasopressin response and the antidiuretic response to hypertonic saline loading were unchanged, but the natriuretic response was attenuated. In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.

Original language	English
Journal	Journal of Applied Physiology
Volume	92
Issue number	5
Pages (from-to)	1911-22
Number of pages	12
ISSN	8750-7587
DOIs	https://doi.org/10.1152/japplphysiol.00936.2001
Publication status	Published - 2002

Keywords

Adaptation, Physiological
Adult
Aldosterone
Altitude
Anoxia
Arginine Vasopressin
Atrial Natriuretic Factor
Blood Pressure
Body Weight
Creatinine
Endothelin-1
Epinephrine
Heart Rate
Humans
Hypertonic Solutions
Infusions, Intravenous
Kidney
Kidney Function Tests
Male
Norepinephrine
Osmolar Concentration
Peptide Fragments
Renin
Sodium Chloride

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10.1152/japplphysiol.00936.2001

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@article{d693c77074c511dbbee902004c4f4f50,

title = "Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men",

abstract = "Effects of hypobaric hypoxemia on endocrine and renal parameters of body fluid homeostasis were investigated in eight normal men during a sojourn of 8 days at an altitude of 4,559 m. Endocrine and renal responses to an osmotic stimulus (5% hypertonic saline, 3.6 ml/kg over 1 h) were investigated at sea level and on day 6 at altitude. Several days of hypobaric hypoxemia reduced body weight (-2.1 +/- 0.4 kg), increased plasma osmolality (+5.3 +/- 1.4 mosmol/kgH(2)O), elevated blood pressure (+12 +/- 1 mmHg), reduced creatinine clearance (122 +/- 6 to 96 +/- 10 ml/min), inhibited the renin system (19.5 +/- 2.0 to 10.9 +/- 0.9 mU/l) and plasma vasopressin (1.14 +/- 0.16 to 0.38 +/- 0.06 pg/ml), and doubled circulating levels of norepinephrine (103 +/- 16 to 191 +/- 35 pg/ml) and endothelin-1 (3.0 +/- 0.2 to 6.3 +/- 0.6 pg/ml), whereas urodilatin excretion rate decreased from day 2 (all changes P <0.05 compared with sea level). Plasma arginine vasopressin response and the antidiuretic response to hypertonic saline loading were unchanged, but the natriuretic response was attenuated. In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.",

keywords = "Adaptation, Physiological, Adult, Aldosterone, Altitude, Anoxia, Arginine Vasopressin, Atrial Natriuretic Factor, Blood Pressure, Body Weight, Creatinine, Endothelin-1, Epinephrine, Heart Rate, Humans, Hypertonic Solutions, Infusions, Intravenous, Kidney, Kidney Function Tests, Male, Norepinephrine, Osmolar Concentration, Peptide Fragments, Renin, Sodium Chloride",

author = "Bestle, {Morten H} and Olsen, {Niels Vidiendal} and Poulsen, {Troels D} and Robert Roach and Niels Fogh-Andersen and Peter Bie",

year = "2002",

doi = "10.1152/japplphysiol.00936.2001",

language = "English",

volume = "92",

pages = "1911--22",

journal = "Journal of Applied Physiology",

issn = "8750-7587",

publisher = "American Physiological Society",

number = "5",

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TY - JOUR

T1 - Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

AU - Bestle, Morten H

AU - Olsen, Niels Vidiendal

AU - Poulsen, Troels D

AU - Roach, Robert

AU - Fogh-Andersen, Niels

AU - Bie, Peter

PY - 2002

Y1 - 2002

N2 - Effects of hypobaric hypoxemia on endocrine and renal parameters of body fluid homeostasis were investigated in eight normal men during a sojourn of 8 days at an altitude of 4,559 m. Endocrine and renal responses to an osmotic stimulus (5% hypertonic saline, 3.6 ml/kg over 1 h) were investigated at sea level and on day 6 at altitude. Several days of hypobaric hypoxemia reduced body weight (-2.1 +/- 0.4 kg), increased plasma osmolality (+5.3 +/- 1.4 mosmol/kgH(2)O), elevated blood pressure (+12 +/- 1 mmHg), reduced creatinine clearance (122 +/- 6 to 96 +/- 10 ml/min), inhibited the renin system (19.5 +/- 2.0 to 10.9 +/- 0.9 mU/l) and plasma vasopressin (1.14 +/- 0.16 to 0.38 +/- 0.06 pg/ml), and doubled circulating levels of norepinephrine (103 +/- 16 to 191 +/- 35 pg/ml) and endothelin-1 (3.0 +/- 0.2 to 6.3 +/- 0.6 pg/ml), whereas urodilatin excretion rate decreased from day 2 (all changes P <0.05 compared with sea level). Plasma arginine vasopressin response and the antidiuretic response to hypertonic saline loading were unchanged, but the natriuretic response was attenuated. In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.

AB - Effects of hypobaric hypoxemia on endocrine and renal parameters of body fluid homeostasis were investigated in eight normal men during a sojourn of 8 days at an altitude of 4,559 m. Endocrine and renal responses to an osmotic stimulus (5% hypertonic saline, 3.6 ml/kg over 1 h) were investigated at sea level and on day 6 at altitude. Several days of hypobaric hypoxemia reduced body weight (-2.1 +/- 0.4 kg), increased plasma osmolality (+5.3 +/- 1.4 mosmol/kgH(2)O), elevated blood pressure (+12 +/- 1 mmHg), reduced creatinine clearance (122 +/- 6 to 96 +/- 10 ml/min), inhibited the renin system (19.5 +/- 2.0 to 10.9 +/- 0.9 mU/l) and plasma vasopressin (1.14 +/- 0.16 to 0.38 +/- 0.06 pg/ml), and doubled circulating levels of norepinephrine (103 +/- 16 to 191 +/- 35 pg/ml) and endothelin-1 (3.0 +/- 0.2 to 6.3 +/- 0.6 pg/ml), whereas urodilatin excretion rate decreased from day 2 (all changes P <0.05 compared with sea level). Plasma arginine vasopressin response and the antidiuretic response to hypertonic saline loading were unchanged, but the natriuretic response was attenuated. In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.

KW - Adaptation, Physiological

KW - Adult

KW - Aldosterone

KW - Altitude

KW - Anoxia

KW - Arginine Vasopressin

KW - Atrial Natriuretic Factor

KW - Blood Pressure

KW - Body Weight

KW - Creatinine

KW - Endothelin-1

KW - Epinephrine

KW - Heart Rate

KW - Humans

KW - Hypertonic Solutions

KW - Infusions, Intravenous

KW - Kidney

KW - Kidney Function Tests

KW - Male

KW - Norepinephrine

KW - Osmolar Concentration

KW - Peptide Fragments

KW - Renin

KW - Sodium Chloride

U2 - 10.1152/japplphysiol.00936.2001

DO - 10.1152/japplphysiol.00936.2001

M3 - Journal article

C2 - 11960941

SN - 8750-7587

VL - 92

SP - 1911

EP - 1922

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 5

ER -

Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

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Keywords

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