Research output per year
Research output per year
Personal profile
Short presentation
Computational chemist and protein modeller, with strong experience and track-record in small molecule and peptides identefication covering a variety of family targets, drug discovery and hit-to-lead optimization programes.
CV
Highly skilled and motivated computational chemist (4+ years), with special focus on CADD, homology modeling, VS, SBDD, cheminformatics, SAR and pharmacophore modeling (Ph.D. Computational Chemistry)
In depth chemistry understanding and knowledge (M.Sc. Medicinal Chemistry).
Sharp writing skills, with a proven track-record of learned and applied research skills/techniques (Published three 1st & One 2nd authorship peer-reviewed scientific articles).
Deeply enjoys working on projects with colleagues from different backgrounds e.g. pharmacology and synthetic chemistry to answer a challenging scientific problem (Completed highly interdisciplinary M.Sc. & Ph.D. projects & stayed for half a year in USA on an independent scientific research stay)
Excellent communication and presentation skills (Oral & poster presentations in international conferences)
Education/Academic qualification
University of Copenhagen
Award Date: 2 May 2018
University of Copenhagen
Award Date: 2 Dec 2015
Pharmacy, German University in Cairo
Award Date: 15 Jul 2010
Keywords
- Faculty of Health and Medical Sciences
- CADD
- Computational Modeling
- Drug design
- Computational Chemistry
- Computational biology
- Cheminformatics
- Structural Biology
- SBDD
- SAR
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Research output
- 5 Journal article
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Identification of a novel scaffold for a small molecule GPR139 receptor agonist
Nøhr, A. C., Shehata, M. A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, P. R., Gloriam, D. E. & Bräuner-Osborne, H., 1 Dec 2019, In: Scientific Reports. 9, 1, p. 3802Research output: Contribution to journal › Journal article › Research › peer-review
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The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site
Shehata, M. A., Jensen, A. C. N., Jespers, W., Floryan, L., Isberg, V., Andersen, K. B., Åqvist, J., Gutiérrez-de-Terán, H., Bräuner-Osborne, H. & Gloriam, D. E., 1 Dec 2017, In: Scientific Reports. 7, 9 p., 1128.Research output: Contribution to journal › Journal article › Research › peer-review
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The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
Jensen, A. C. N., Shehata, M. A., Hauser, A. S., Isberg, V., Mokrosinski, J., Farooqi, I. S., Pedersen, D. S., Gloriam, D. E. & Bräuner-Osborne, H., 1 Jan 2017, In: Neurochemistry International. 102, p. 105-113Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
Shehata, M. A., Jensen, A. C. N., Lissa, D., Bisig, C., Isberg, V., Andersen, K. B., Harpsøe, K., Björkling, F., Bräuner-Osborne, H. & Gloriam, D. E., 10 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 36681.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of the first surrogate agonists for the G protein-coupled receptor GPR132
Shehata, M. A., Christensen, H. B., Isberg, V., Pedersen, D. S., Bender, A., Bräuner-Osborne, H. & Gloriam, D. E., 2015, In: RSC Advances. 5, p. 48551-48557 7 p.Research output: Contribution to journal › Journal article › Research › peer-review