Kirstine G Belling

Research output

Research output per year 2012 2015 2017 2018 2019

• 23 Journal article
• 1 Book chapter
• 1 Conference abstract in journal
• 1 Editorial
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  Comorbidity landscape of the Danish patient population affected by chromosome abnormalities

  Jørgensen, I. F., Russo, F., Jensen, A. B., Westergaard, D., Lademann, M., Hu, J. X., Brunak, S. & Belling, K., 1 Nov 2019, In: Genetics In Medicine. 21, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosome Aberrations 100%
  • Comorbidity 80%
  • Fragile X Syndrome 66%
  • Down Syndrome 53%
  • Population 40%
  4 Citations (Scopus)

  2 Downloads (Pure)
• 2018

  Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

  Matey-Hernandez, M. L., Danish Pan Genome Consortium, Brunak, S., Izarzugaza, J. M. G., Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Belling, K. G., Have, C. T., Bork-Jensen, J., Sun, J., Hansen, T., Krogh, A., Sørensen, T. I. A., Pedersen, O. B., Wang, J., Eiberg, H. R. L. & Kristiansen, K., 2018, In: BMC Bioinformatics. 19, p. 1-12 239.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Leukocytes 100%
  • Benchmarking 89%
  • Antigens 85%
  • HLA Antigens 65%
  • Human 56%
  8 Citations (Scopus)

  69 Downloads (Pure)

• Comorbidity landscape of the Danish patient population affected by chromosomal abnormalities

  Russo, F., Jørgensen, I. F., Westergaard, D., Jensen, A. B., Hu, J. X., Belling, K. & Brunak, S., 2018, In: European Journal of Human Genetics. 26, p. 697-698

  Research output: Contribution to journal › Conference abstract in journal › Research

  14 Citations (Scopus)

• miRandola 2017: a curated knowledge base of non-invasive biomarkers

  Russo, F., Di Bella, S., Vannini, F., Berti, G., Scoyni, F., Cook, H. V., Santos, A., Nigita, G., Bonnici, V., Laganà, A., Geraci, F., Pulvirenti, A., Giugno, R., De Masi, F., Belling, K., Jensen, L. J., Brunak, S., Pellegrini, M. & Ferro, A., 1 Jan 2018, In: Nucleic Acids Research. 46, D1, p. D354-D359 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Knowledge Bases 100%
  • Untranslated RNA 93%
  • Biomarkers 53%
  • Exosomes 32%
  • Databases 24%
  31 Citations (Scopus)

  79 Downloads (Pure)

• The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

  Russo, F., De Masi, F., Brunak, S. & Belling, K. G., 2018, Systems Biology. Rajewsky, N., Jurga, S. & Barciszewski, J. (eds.). Springer, p. 229-238 (RNA Technologies).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • XIST non-coding RNA 100%
  • X Chromosome Inactivation 73%
  • Untranslated RNA 63%
  • Long Noncoding RNA 40%
  • MicroRNAs 31%

• Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells

  Winge, S. B., Dalgaard, M. D., Belling, K. G., Jensen, J. M., Nielsen, J. E., Aksglaede, L., Schierup, M. H., Brunak, S., Skakkebæk, N. E., Juul, A., Rajpert-De Meyts, E. & Almstrup, K., 1 Jun 2018, In: Cell Death & Disease. 9, 6, 14 p., 586.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Leydig Cells 100%
  • Sertoli Cells 99%
  • Gene Expression Profiling 86%
  • Testis 74%
  • Sertoli Cell-Only Syndrome 45%
  11 Citations (Scopus)

  49 Downloads (Pure)
• 2017

  Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion

  Danish Pan Genome Consortium, Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Belling, K. G., Have, C. T., Bork-Jensen, J., Hansen, T., Krogh, A., Sørensen, T. I. A., Pedersen, O. B., Rasmussen, S., Kristiansen, K. & Brunak, S., Aug 2017, In: PLOS Genetics. 13, 8, p. e1006834

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosomes, Human, Y 100%
  • Gene Conversion 84%
  • gene conversion 78%
  • Y Chromosome 76%
  • Y chromosome 67%
  15 Citations (Scopus)

• Assembly and analysis of 100 full MHC haplotypes from the Danish population

  Jensen, J. M., Villesen, P., Friborg, R. M., Mailund, T., Besenbacher, S., Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R., & 39 othersYe, W., Rao, J., Guo, X., Sun, J., Cao, H., Ye, C., Beusekom, J. V., Espeseth, T., Flindt, E., Halager, A. E., Hellard, S. L., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, D., Yadav, R., Li, N., Xu, X., Hansen, T., Bolund, L., Krogh, A., Sørensen, T. I. A., Pedersen, O. B., Gupta, R., Rasmussen, S., Børglum, A. D., Wang, J., Eiberg, H. R. L., Kristiansen, K., Brunak, S. & Schierup, M. H., Sept 2017, In: Genome Research. 27, 9, p. 1597-1607 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Haplotypes 100%
  • Genome 72%
  • Linkage Disequilibrium 60%
  • Genome-Wide Association Study 55%
  • Major Histocompatibility Complex 54%
  7 Citations (Scopus)

  150 Downloads (Pure)

• Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations

  Kirk, I. K., Weinhold, N., Belling, K., Skakkebæk, N. E., Jensen, T. S., Leffers, H., Juul, A. & Brunak, S., 22 Mar 2017, In: Cell Systems. 4, 3, 11 p., 357-364.e3.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosomes 100%
  • Gene Dosage 67%
  • Proteins 46%
  • Trisomy 34%
  • Chromosomes, Human, Pair 21 18%
  6 Citations (Scopus)

  66 Downloads (Pure)

• Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents

  Lottrup, G., Belling, K., Leffers, H., Nielsen, J. E., Dalgaard, M. D., Juul, A., Skakkebæk, N. E., Brunak, S. & Meyts, E. R-D., 1 May 2017, In: Molecular Human Reproduction. 23, 5, p. 339-354 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Leydig Cells 100%
  • Transcriptome 77%
  • Testis 28%
  • Genes 25%
  • Hydroxyprostaglandin Dehydrogenases 21%
  5 Citations (Scopus)

• Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

  Belling, K., Russo, F., Jensen, A. B., Dalgaard, M. D., Westergaard, D., Rajpert-De Meyts, E., Skakkebæk, N. E., Juul, A. & Brunak, S., 1 Apr 2017, In: Human Molecular Genetics. 26, 7, p. 1219-1229 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Klinefelter Syndrome 100%
  • X-Linked Genes 92%
  • Gene Dosage 85%
  • Comorbidity 56%
  • Systems Biology 28%
  35 Citations (Scopus)

  75 Downloads (Pure)

• MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

  Russo, F., Belling, K., Jensen, A. B., Scoyni, F., Brunak, S. & Pellegrini, M., 2017, In: Methods in molecular biology (Clifton, N.J.). 1580, p. 281-295 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNAs 100%
  • Comorbidity 92%
  • Messenger RNA 38%
  • Disease Progression 27%
  • Small Untranslated RNA 20%
  1 Citation (Scopus)

• Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice

  Doroszko, M., Chrusciel, M., Belling, K. G., Vuorenoja, S., Dalgaard, M., Leffers, H., Nielsen, H. B., Huhtaniemi, I., Toppari, J. & Rahman, N. A., 15 Mar 2017, In: Molecular and Cellular Endocrinology. 444, p. 9-18 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glandular and Epithelial Neoplasms 100%
  • Inhibins 91%
  • Gonadotropins 87%
  • Simian virus 40 83%
  • Viral Tumor Antigens 82%
  4 Citations (Scopus)

• Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

  Sørensen, L. M., Jensen, J. M., Petersen, B., Sibbesen, J. A., Liu, S., Villesen, P., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R., Ye, W., Rao, J., Guo, X., & 39 othersSun, J., Cao, H., Ye, C., van Beusekom, J., Espeseth, T., Flindt, E., Friborg, R. M., Halager, A. E., Le Hellard, S., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Mailund, T., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, D., Yadav, R., Li, N., Xu, X., Hansen, T., Krogh, A., Bolund, L., Sørensen, T. I. A., Pedersen, O. B., Gupta, R., Rasmussen, S., Besenbacher, S., Børglum, A. D., Wang, J., Eiberg, H. R. L., Kristiansen, K., Brunak, S. & Schierup, M. H., 3 Aug 2017, In: Nature. 548, 7665, p. 87-91 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Denmark 100%
  • Genome 63%
  • Genetic Variation 60%
  • Catalogs 39%
  • Y Chromosome 38%
  52 Citations (Scopus)

  291 Downloads (Pure)

• The impact of the protein interactome on the syntenic structure of mammalian genomes

  Kirk, I. K., Weinhold, N., Brunak, S. & Belling, K., Sept 2017, In: PLOS ONE. 12, 9, 14 p., e0179112.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein-protein Interaction 100%
  • protein-protein interactions 94%
  • Genome 93%
  • Protein 88%
  • Genomics 88%
  4 Citations (Scopus)

  57 Downloads (Pure)
• 2016

  The hunt for fatal myocardial infarction biomarkers: predictive circulating microRNAs

  Russo, F., Rizzo, M., Belling, K., Brunak, S. & Folkersen, L., Oct 2016, In: Journal of Translational Medicine. 4, Suppl 1, 4 p., S1.

  Research output: Contribution to journal › Editorial
• 2015

  Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways

  Hansen, S. N., Westergaard, D., Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, K. G., Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, J., Brünner, N., Stenvang, J. & Rasmussen, A-S. S., 11 Jun 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Docetaxel 100%
  • Up-Regulation 64%
  • Breast Neoplasms 57%
  • Glycoproteins 45%
  • Permeability 38%
  25 Citations (Scopus)

• Discovery, genotyping and characterization of structural variation and novel sequence at single nucleotide resolution from de novo genome assemblies on a population scale

  Danish Pan Genome Consortium, Belling, K. G. & Rasmussen, S., 2015, In: GigaScience. 4, 13 p., 64.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nucleotides 100%
  • Genomics 83%
  • Genome 54%
  • Population 31%
  • Polymorphism 16%
  9 Citations (Scopus)

  198 Downloads (Pure)

• Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance

  Jensen, N. F., Stenvang, J., Beck, M. K., Hanáková, B., Belling, K. C., Do, K. N., Viuff, B. M., Nygård, S. B., Gupta, R., Rasmussen, M. H., Tarpgaard, L. S., Hansen, T. P., Budinská, E., Pfeiffer, P., Bosman, F., Tejpar, S., Roth, A., Delorenzi, M., Andersen, C. L., Rømer, M. U. K., & 2 othersBrünner, N. & Moreira, J., 1 Jun 2015, In: Molecular Oncology. 9, 6, p. 1169-1185 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Colorectal Neoplasms 100%
  • Oxaliplatin 89%
  • Irinotecan 88%
  • Cell Line 74%
  • Drug Therapy 74%
  42 Citations (Scopus)

• Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

  Besenbacher, S., Liu, S., Gonzalez-Izarzugaza, J. M., Grove, J., Belling, K. G., Bork-Jensen, J., Huang, S., Als, T. D., Li, S., Yadav, R., Rubio García, A., Lescai, F., Demontis, D., Rao, J., Ye, W., Mailund, T., Møllegaard Friborg, R., Pedersen, C. N. S., Xu, R., Sun, J., & 27 othersLiu, H., Wang, O., Cheng, X., Flores, D., Rydza, E. K., Rapacki, K., Sørensen, J. D., Chmura, P. J., Westergaard, D., Dworzynski, P., Sørensen, T. I. A., Lund, O., Hansen, T., Xu, X., Li, N., Bolund, L., Pedersen, O., Eiberg, H., Krogh, A., Børglum, A. D., Brunak, S., Kristiansen, K., Schierup, M. H., Wang, J., Gupta, R., Villesen, P. & Rasmussen, S., Jan 2015, In: Nature Communications. 6, 9 p., 5969.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • nucleotides 100%
  • mutations 92%
  • Mutation Rate 84%
  • Mutation 67%
  • Nucleotide 65%
  90 Citations (Scopus)

  122 Downloads (Pure)

• The potential role of Alu Y in the development of resistance to SN38 (Irinotecan) or oxaliplatin in colorectal cancer

  Lin, X., Stenvang, J., Rasmussen, M. H., Zhu, S., Jensen, N. F., Tarpgaard, L. S., Yang, G., Belling, K., Andersen, C. L., Li, J., Bolund, L. & Brünner, N., 22 May 2015, In: BMC Genomics. 16, 17 p., 404.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oxaliplatin 100%
  • Irinotecan 99%
  • DNA Methylation 83%
  • Colorectal Neoplasms 67%
  • hydrogen sulfite 43%
  8 Citations (Scopus)

  71 Downloads (Pure)
• 2014

  The transcriptome of corona radiata cells from individual MII oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women

  Wissing, M. L., Sonne, S. B., Westergaard, D., do Nguyen, K., Belling, K., Høst, T. & Mikkelsen, A. L., 2014, In: Journal of Ovarian Research. 7, 110, 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Intracytoplasmic Sperm Injections 100%
  • Embryo Transfer 98%
  • Polycystic Ovary Syndrome 94%
  • Oocytes 79%
  • Transcriptome 77%
  8 Citations (Scopus)

  433 Downloads (Pure)
• 2013

  TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells

  Hekmat, O., Munk, S., Fogh, L., Yadav, R., Francavilla, C., Horn, H., Würtz, S. Ø., Schrohl, A-S., Damsgaard, B., Romer, M. U., Belling, K., Jensen, N. F., Gromova, I., Bekker-Jensen, D. B., Moreira, J., Jensen, L. J., Gupta, R., Lademann, U. A., Brünner, N., Olsen, J. V., & 1 othersStenvang, J., 6 Sept 2013, In: Journal of Proteome Research. 12, 9, p. 4136-4151 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tissue Inhibitor of Metalloproteinase-1 100%
  • Drug Resistance 76%
  • Phosphorylation 57%
  • Breast Neoplasms 53%
  • Topoisomerase Inhibitor 46%
  24 Citations (Scopus)

• TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression

  Bjerre, C. A., Jensen, L. V., Belling, K. C., Würtz, S. Ø., Yadav, R., Lademann, U. A., Rigina, O., Do, K. N., Ditzel, H. J., Lykkesfeldt, A. E., Wang, J., Nielsen, H. B., Brünner, N., Gupta, R., Rasmussen, A-S. S. & Stenvang, J., Dec 2013, In: Tumor Biology. 34, 6, p. 3839-3851 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fulvestrant 100%
  • Tissue Inhibitor of Metalloproteinase-1 89%
  • Progesterone Receptors 78%
  • Down-Regulation 52%
  • Breast Neoplasms 47%
  11 Citations (Scopus)

• Transcriptome profiling of mice testes following low dose irradiation

  Belling, K. C., Nielsen, H. B., Brunak, S., Tanaka, M., Dalgaard, M. D., Nielsen, J. E., Almstrup, K. & Leffers, H., 28 May 2013, In: Reproductive Biology and Endocrinology. 11, 1, 13 p., 50.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gene Expression Profiling 100%
  • Testis 86%
  • Hyperplasia 36%
  • Spermatids 34%
  • Leydig Cells 32%
  7 Citations (Scopus)
• 2012

  Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells

  Welsh, M., Moffat, L., Belling, K., de França, L. R., Segatelli, T. M., Saunders, P. T. K., Sharpe, R. M. & Smith, L. B., Feb 2012, In: International Journal of Andrology. Supplement. 35, 1, p. 25-40 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Leydig Cells 100%
  • Androgen Receptors 90%
  • Testosterone 27%
  • Population 16%
  • Steroidogenic Factor 1 15%
  46 Citations (Scopus)

• MicroRNA expression profiling of carcinoma in situ cells of the testis

  Novotny, G. W., Belling, K. C., Bramsen, J. B., Nielsen, J. E., Bork-Jensen, J., Almstrup, K., Sonne, S. B., Kjems, J., Rajpert-De Meyts, E. & Leffers, H., Jun 2012, In: Endocrine - Related Cancer. 19, p. 365-379 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Carcinoma in Situ 100%
  • Testis 78%
  • MicroRNAs 74%
  • Seminoma 37%
  • Embryonal Carcinoma 27%
  70 Citations (Scopus)