Jukka Rantanen

Research output

Research output per year 2002 2007 2012 2013 2017 2019 2020

• 231 Journal article
• 7 Conference abstract in journal
• 5 Conference article
• 5 Review
• 5 More
  • 2 Paper
  • 1 Editorial
  • 1 Letter
  • 1 Net publication - Internet publication

Research output per year

Research output per year

Search results

• 2012

  Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers

  Xia, D., Wu, J-X., Cui, F., Qu, H., Rades, T., Rantanen, J. & Yang, M., 15 Aug 2012, In: European Journal of Pharmaceutical Sciences. 46, 5, p. 446-454 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nitrendipine 100%
  • Crystallization 68%
  • Polymers 63%
  • Suspensions 62%
  • Powder Diffraction 43%
  15 Citations (Scopus)

• Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

  Aksu, B., De Beer, T., Folestad, S., Ketolainen, J., Lindén, H., Lopes, J. A., de Matas, M., Oostra, W., Rantanen, J. & Weimer, M., 29 Sept 2012, In: European Journal of Pharmaceutical Sciences. 47, 2, p. 402-405 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pharmaceutical 100%
  • Technology 89%
  • Biological Products 67%
  • Pharmaceutical Preparations 56%
  • Costs and Cost Analysis 42%
  36 Citations (Scopus)

• Structural elucidationof rapid solution-mediatedPhase transitions in pharmaceutical solids using in situ synchrotron SAXS/WAXS

  Bøtker, J. P., Rades, T., Rantanen, J., Hawley, A. & Boyd, B. J., 4 Sept 2012, In: Molecular Pharmaceutics. 9, 9, p. 2787-2791

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synchrotrons 100%
  • Solubility 71%
  • Pharmaceutical 52%
  • Kinetics 51%
  • Raman Spectrum Analysis 46%
  22 Citations (Scopus)

• The influence of thermal history on the physical behavior of poly(ethylene glycol) (PEG)

  Baldursdóttir, S. G., Tian, F., Santacruz, B. G., Jørgensen, A. C. & Rantanen, J. T., Mar 2012, In: Pharmaceutical Development and Technology. 17, 2, p. 195-203

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ethylene Glycol 100%
  • Cooling 71%
  • Granulation 71%
  • Melting 70%
  • Poly(ethylene Glycol) 65%
  4 Citations (Scopus)
• 2011

  Amorphous formulation development - advantages and drawbacks

  Kogermann, K., Veski, P., Rantanen, J. & Naelapaa, K., 24 Sept 2011, In: European Journal of Pharmaceutical Sciences. 44, supplement 1, p. 22-23 2 p.

  Research output: Contribution to journal › Conference article › Communication

• Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions

  Bøtker, J. P., Karmwar, P., Strachan, C. J., Cornett, C., Tian, F., Zujovic, Z., Rantanen, J. & Rades, T., 30 Sept 2011, In: International Journal of Pharmaceutics. 417, 1-2, p. 112-119 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Distribution Function 100%
  • Powder Diffraction 94%
  • Indomethacin 81%
  • X-Ray Diffraction 73%
  • Disorder 70%
  22 Citations (Scopus)

• Characterization of thermoresponsive PNIPAM polymers for crystal modification of nitrofurantoin

  Munk, T. P., Hietala, S., Kalliomäki, K., Nuopponen, M., Tenhu, H., Tian, F., Rantanen, J. T. & Baldursdóttir, S. G., 2011, In: Polymer Bulletin. 67, p. 677-692

  Research output: Contribution to journal › Journal article › Research › peer-review

  9 Citations (Scopus)

• Crystal engineering: effects of amide/lactam containing additives on the crystallization behaviour of nitrofurantoin monohydrate

  Munk, T. P., Baldursdóttir, S. G. & Rantanen, J. T., 2011. 8 p.

  Research output: Contribution to conference › Paper › Research › peer-review

• Image analysis as tool in fast stability screening of solid dispersions

  Wu, J-X., van der Berg, F. W. J., Amigo Rubio, J. M. & Rantanen, J., 2011

  Research output: Other contribution › Net publication - Internet publication › Research

  952 Downloads (Pure)

• Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability

  Wu, J-X., Yang, M., van der Berg, F. W. J., Pekka Pajander, J., Rades, T. & Rantanen, J., 18 Dec 2011, In: European Journal of Pharmaceutical Sciences. 44, 5, p. 610-620

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Piroxicam 100%
  • Molecular Weight 60%
  • Crystallization 21%
  • Hydrogen Bonding 21%
  • Solubility 18%
  58 Citations (Scopus)

• Influence of temperature on solvent-mediated anhydrate-to-hydrate transformation kinetics

  Qu, H., Munk, T. P., Cornett, C., Wu, J-X., Bøtker, J. P., Christensen, L. P., Rantanen, J. T. & Tian, F., Feb 2011, In: Pharmaceutical Research. 28, 2, p. 364-373

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Kinetics 100%
  • Temperature 99%
  • Supersaturation 88%
  • Chemical Transformation 86%
  • Deceleration 45%
  25 Citations (Scopus)

• Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

  Boetker, J. P., Savolainen, M., Koradia, V., Tian, F., Rades, T., Müllertz, A., Cornett, C., Rantanen, J. & Østergaard, J., 1 Aug 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amlodipine 100%
  • Raman Spectrum Analysis 92%
  • Raman Spectroscopy 52%
  • Dissolution 52%
  • Amorphous Material 32%
  64 Citations (Scopus)

• Investigations on the effect of different cooling rates on the stability of amorphous indomethacin

  Karmwar, P., Bøtker, J. P., Graeser, K. A., Strachan, C. J., Rantanen, J. & Rades, T., 9 Oct 2011, In: European Journal of Pharmaceutical Sciences. 44, 3, p. 341-350

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Indomethacin 100%
  • Crystallization 91%
  • Glass 48%
  • Temperature 36%
  • Transition Temperature 34%
  40 Citations (Scopus)

• Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

  Ostergaard, J., Ye, F., Rantanen, J., Yaghmur, A., Larsen, S. W., Larsen, C. S. & Jensen, H., Aug 2011, In: Journal of Pharmaceutical Sciences. 100, 8, p. 3405-3410

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lidocaine 100%
  • Dissolution 55%
  • Single Crystalline Solid 52%
  • Biopharmaceutics 18%
  • Convection 17%
  45 Citations (Scopus)

• Particle size dependence of polymorphism in spray-dried mannitol

  Lee, Y-Y., Wu, J-X., Yang, M., Young, P. M., van der Berg, F. W. J. & Rantanen, J., 18 Sept 2011, In: European Journal of Pharmaceutical Sciences. 44, 1-2, p. 41-48

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mannitol 100%
  • Particle Size 90%
  • Muramidase 27%
  • Powder Diffraction 24%
  • Powders 23%
  40 Citations (Scopus)

• Perspective on water of crystallization affecting the functionality of pharmaceuticals

  Tian, F. & Rantanen, J., Jun 2011, In: Food Biophysics. 6, 2, p. 250-258

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Crystallization 100%
  • Drug products 90%
  • crystallization 82%
  • Hydrate 77%
  • Hydrates 61%
  2 Citations (Scopus)

• Phase transformations of amlodipine besylate solid forms

  Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Müllertz, A. & Rantanen, J. T., Jul 2011, In: Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amlodipine 100%
  • Solubility 70%
  • Drug Storage 58%
  • Kinetics 50%
  • Granulation 46%
  17 Citations (Scopus)

• Rapid solid-state analysis of freeze-dried protein formulations using NIR and raman spectroscopies

  Grohganz, H., Gildemyn, D., Skibsted, E., Flink, J. M. & Rantanen, J. T., Jul 2011, In: Journal of Pharmaceutical Sciences. 100, 7

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Raman Spectrum Analysis 100%
  • Near-Infrared Spectroscopy 91%
  • Mannitol 87%
  • NIR Spectroscopy 77%
  • Raman Spectroscopy 57%
  16 Citations (Scopus)

• Stabilization of liposomes during drying

  Ingvarsson, P. Þ., Yang, M., Nielsen, H. M., Rantanen, J. T. & Foged, C., Mar 2011, In: Expert Opinion on Drug Delivery. 8, 3, p. 375-388

  Research output: Contribution to journal › Review

  • Liposomes 100%
  • Liposome 93%
  • Drug 40%
  • Refrigeration 35%
  • Vitrification 34%
  71 Citations (Scopus)

• X-ray powder diffractormetry in combination with principal component analysis - A tool for monitoring solid state changes

  Kogermann, K., Veski, P., Rantanen, J. T. & Naelapaa, K., 17 Jul 2011, In: European Journal of Pharmaceutical Sciences. 43, p. 278-289

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Piroxicam 100%
  • Principal Component Analysis 76%
  • Powders 72%
  • X-Rays 55%
  • Temperature 22%
  20 Citations (Scopus)
• 2010

  A novel hybrid chromatography - crystallization process for the isolation and purification of a natural pharmaceutical ingredient from a medicinal herb

  Qu, H., Christensen, K. B., Fretté, X. C., Tian, F., Qu, H., Rantanen, J. & Christensen, L. P., 21 May 2010, In: Organic Process Research and Development. 14, 3, p. 585-591

  Research output: Contribution to journal › Journal article › Research › peer-review

  • chromatography 100%
  • purification 89%
  • ingredients 80%
  • isolation 73%
  • Salting Out 61%
  8 Citations (Scopus)

• Building quality into a coating process

  Naelapaa, K., Veski, P., Kristensen, H. G., Rantanen, J. T. & Bertelsen, P., Feb 2010, In: Pharmaceutical Development and Technology. 15, 1, p. 35-45

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coating Process 100%
  • Filtration 73%
  • Research Design 67%
  • Coating Agent 50%
  • Risk Management 46%
  10 Citations (Scopus)

• Building the quality into pellet manufacturing environment - Feasibility study and validation of an in-line quantitative near infrared (NIR) method

  Mantanus, J., Ziémons, E., Rozet, E., Streel, B., Klinkenberg, R., Evrard, B., Rantanen, J. T. & Hubert, P., 15 Dec 2010, In: Talanta: The International Journal of Pure and Applied Analytical Chemistry. 83, 2, p. 305-311

  Research output: Contribution to journal › Journal article › Research

  • Pellet 100%
  • Environment 58%
  • Error 51%
  • Pharmaceutical 50%
  34 Citations (Scopus)

• Chromatography-crystallization hybrid process for artemisinin purification from artemisia annua

  Qu, H., Christensen, K. B., Fretté, X., Tian, F., Rantanen, J. & Christensen, L. P., May 2010, In: Chemical Engineering and Technology. 33, 5, p. 791-796

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatography 100%
  • Purification 82%
  • Crystallization 79%
  • Salting Out 51%
  • Column Chromatography 27%
  20 Citations (Scopus)

• Classification of lyophilised mixtures using multivariate analysis of NIR spectra

  Grohganz, H., Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, J. T., Feb 2010, In: European Journal of Pharmaceutics and Biopharmaceutics. 74, p. 406-412

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Near-Infrared Spectrum 100%
  • Mannitol 98%
  • Excipient 88%
  • Multivariate Analysis 58%
  • Excipients 54%
  18 Citations (Scopus)

• Crystallization of polymorphic hydrate system

  Tian, F., Qu, H., Louhi-Kultanen, M. & Rantanen, J. T., Feb 2010, In: Journal of Pharmaceutical Sciences. 99, p. 753-763

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Crystallization 100%
  • Hydrate 77%
  • Solubility 27%
  • Nitrofurantoin 18%
  • Seeds 14%
  8 Citations (Scopus)

• Factors affecting crystallization of hydrates

  Tian, F., Qu, H., Zimmermann, A., Munk, T. P., Jørgensen, A. C. & Rantanen, J. T., Nov 2010, In: Journal of Pharmacy and Pharmacology. 62, 11, p. 1534-1546

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Crystallization 100%
  • Hydrate 77%
  • Thermodynamics 50%
  • Pharmaceutical Preparations 34%
  • Kinetics 29%
  52 Citations (Scopus)

• Integrated approach to study the dehydration kinetics of nitrofurantoin monohydrate

  Koradia, V. S., Diego, H. L. D., Elema, M. R. & Rantanen, J. T., Sept 2010, In: Journal of Pharmacy and Pharmaceutical Sciences. 99, 9, p. 3966-3976

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nitrofurantoin 100%
  • Dehydration 69%
  • Kinetics 47%
  • Powder Diffraction 37%
  • X-Ray Diffraction 29%
  27 Citations (Scopus)

• Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

  Koradia, V. S., Lopez de Diego, H., Frydenvang, K. A., Ringkjøbing-Elema, M., Müllertz, A., Bond, A. D. & Rantanen, J., 1 Dec 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amlodipine 100%
  • Crystal structure 89%
  • Solubility 77%
  • solubility 63%
  • coronary artery disease 61%
  24 Citations (Scopus)

• Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

  Grohganz, H., Gildemyn, D., Skibsted, E., Fink, J. M. & Rantanen, J. T., Aug 2010, In: Analytica Chimica Acta. 676, p. 34-40

  Research output: Contribution to journal › Journal article › Research › peer-review

  • NIR Spectroscopy 100%
  • Error 74%
  • Excipient 71%
  • Mannitol 39%
  • Sucrose 31%
  22 Citations (Scopus)

• Towards effective solid form screening

  Allesø, M., Tian, F., Cornett, C. & Rantanen, J. T., Sept 2010, In: Journal of Pharmaceutical Sciences. 99, 9, p. 3711-3718

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nifedipine 100%
  • Crystallization 60%
  • Theophylline 59%
  • Amorphous Material 34%
  • Chemical Transformation 31%
  34 Citations (Scopus)
• 2009

  An insight into water of crystallization during processing using vibrational spectroscopy

  Jørgensen, A. C., Strachan, C. J., Pöllänen, K. H., Koradia, V. S., Tian, F. & Rantanen, J. T., 2009, In: Journal of Pharmaceutical Sciences. 98, 11, p. 3903-3932

  Research output: Contribution to journal › Review

  34 Citations (Scopus)

• Crystal morphology engineering of pharmaceutical solids: Tabletting performance enhancement

  Mirza, S., Miroshnyk, I., Heinämäki, J., Antikainen, O., Rantanen, J. T., Vuorela, P., Vuorela, H. & Yliruusi, J., 2009, In: AAPS PharmSciTech. 10, 1, p. 113-119

  Research output: Contribution to journal › Journal article › Research › peer-review

  26 Citations (Scopus)

• Effects of polymer additives on the crystallization of hydrates: A molecular-level modulation: a molecular-level modulation

  Tian, F., Baldursdóttir, S. G. & Rantanen, J. T., 2009, In: Molecular Pharmaceutics. 6, 1, p. 202-210

  Research output: Contribution to journal › Journal article › Research › peer-review

  27 Citations (Scopus)

• Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation

  Allesø, M., Chieng, N., Rehder, S., Rantanen, J. T., Rades, T. & Aaltonen, J., 2009, In: Journal of Controlled Release. 136, p. 45-53

  Research output: Contribution to journal › Journal article › Research › peer-review

  185 Citations (Scopus)

• Increasing process understanding by analyzing complex interactions in experimental data

  Naelapaa, K., Allesø, M., Kristensen, H. G., Bro, R., Rantanen, J. T. & Bertelsen, P., 2009, In: Journal of Pharmaceutical Sciences. 98, 5, p. 1852-1861 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  17 Citations (Scopus)

• Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

  Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, J. T., Müllertz, A. & Hovgaard, L., 2009, In: Pharmaceutical Research. 26, 4, p. 846-854

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate

  Tian, F., Qu, H., Louhi-Kultanen, M. & Rantanen, J. T., 2009, In: Journal of Crystal Growth. 311, p. 2580-2589

  Research output: Contribution to journal › Journal article › Research › peer-review

  16 Citations (Scopus)

• Rheological behaviour of poly(N-isopropyl acrylamide) in water-acetone mixtures

  Munk, T. P., Hietala, S., Kalliomäki, K., Nuopponen, M., Tenhu, H., Tian, F., Rantanen, J. T. & Baldursdóttir, S. G., 2009, In: Nordic Rheology Society Annual Transactions. 17, p. 113-118 6 p.

  Research output: Contribution to journal › Conference article › Research

• Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

  Grohganz, H., Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, J. T., 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 901-907

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)

• Solid form screening: A review

  Aaltonen, J., Allesø, M., Mirza, S., Koradia, V. S., Gordon, K. C. & Rantanen, J. T., 2009, In: European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 23-37

  Research output: Contribution to journal › Review

  201 Citations (Scopus)

• Solvent-mediated solid phase transformations of carbamazepine: effects of simulated intestinal fluid and fasted state simulated intestinal fluid

  Lehto, P., Aaltonen, J., Tenho, M., Rantanen, J. T., Hirvonen, J., Tanninen, V. P. & Peltonen, L., 2009, In: Journal of Pharmaceutical Sciences. 98, 3, p. 985-996

  Research output: Contribution to journal › Journal article › Research › peer-review

  47 Citations (Scopus)

• Structural characterisation and dehydration behaviour of siramesine hydrochloride

  Zimmermann, A., Tian, F., Lopez de Diego, H., Frydenvang, K. A., Rantanen, J. T., Elema, M. R. & Hovgaard, L., 2009, In: Journal of Pharmaceutical Sciences. 98, 10, p. 3596-3607

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)
• 2008

  Building the quality into manufacturing of macromolecular systems

  Rantanen, J. T., 2008, In: European Journal of Pharmaceutical Sciences. 34, 1, p. S11

  Research output: Contribution to journal › Conference abstract in journal › Research

• Controlling production process: incorporating analytical methods

  Grohganz, H. & Rantanen, J. T., 2008, In: Pharma focus Asia. 8, p. 82-83

  Research output: Contribution to journal › Journal article › Communication

• Controlling solid state properties of pharmaceuticals with polymer selection

  Baldursdóttir, S. G., Tian, F. & Rantanen, J. T., 2008, In: Nordic Rheology Society Annual Transactions.

  Research output: Contribution to journal › Conference article › Research

• Editorial

  Reinikainen, S-P., Taavitsainen, V-M. & Rantanen, J. T., 2008, In: Journal of Chemometrics. 22, 11-12, p. 563-564

  Research output: Contribution to journal › Editorial

• Establishing quantitative in-line analysis of multiple solid-state transformations during dehydration

  Kogermann, K., Aaltonen, J., Strachan, C. J., Pöllänen, K., Heinämäki, J., Yliruusi, J. & Rantanen, J. T., 2008, In: Journal of Pharmaceutical Sciences. 97, 11, p. 4983-4999

  Research output: Contribution to journal › Journal article › Research › peer-review

  43 Citations (Scopus)

• Hydroxypropyl methylcellulose-controlled crystallization of erythromycin a dihydrate crystals with modified morphology

  Mirza, S., Miroshnyk, I., Heinämäki, J., Rantanen, J. T., Antikainen, O., Vuorela, P., Vuorela, H. & Yliruusi, J., 2008, In: Crystal Growth & Design. 8, 10, p. 3526-3531

  Research output: Contribution to journal › Journal article › Research › peer-review

  18 Citations (Scopus)

• Identifying sources of batch to batch variation in processability

  Hagsten, A., Larsen, C. C., Møller-Sonnergaard, J., Rantanen, J. T. & Hovgaard, L., 2008, In: Powder Technology. 183, 2, p. 213-219

  Research output: Contribution to journal › Journal article › Research › peer-review

  17 Citations (Scopus)