Perspective on water of crystallization affecting the functionality of pharmaceuticals

TY - JOUR

T1 - Perspective on water of crystallization affecting the functionality of pharmaceuticals

AU - Tian, Fang

AU - Rantanen, Jukka

PY - 2011/6

Y1 - 2011/6

N2 - Water can be incorporated into crystalline lattice of organic molecules in several ways and thus forms systems with different molecular packing characteristics. This review outlines a general classification of hydrates and explains why it is of high relevance for pharmaceutical researchers to investigate water of crystallization and hydrate systems. The different manufacturing steps related to the final drug product are also briefly discussed with an emphasis on the role of water and possible solid-state transformations related to hydrates. Application of spectroscopic techniques in characterizing water of crystallization and the effect of water on the drug and formulation stability are presented. Moreover, the role of water on the in vitro drug dissolution behavior is reviewed where an example is shown to illustrate the recent development on correlating solid state of the drug, for instance, hydrate formation, to the dissolution profile of the product, to achieve a better understanding of the dissolution process.

AB - Water can be incorporated into crystalline lattice of organic molecules in several ways and thus forms systems with different molecular packing characteristics. This review outlines a general classification of hydrates and explains why it is of high relevance for pharmaceutical researchers to investigate water of crystallization and hydrate systems. The different manufacturing steps related to the final drug product are also briefly discussed with an emphasis on the role of water and possible solid-state transformations related to hydrates. Application of spectroscopic techniques in characterizing water of crystallization and the effect of water on the drug and formulation stability are presented. Moreover, the role of water on the in vitro drug dissolution behavior is reviewed where an example is shown to illustrate the recent development on correlating solid state of the drug, for instance, hydrate formation, to the dissolution profile of the product, to achieve a better understanding of the dissolution process.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s11483-011-9217-0

DO - 10.1007/s11483-011-9217-0

M3 - Journal article

SN - 1557-1858

VL - 6

SP - 250

EP - 258

JO - Food Biophysics

JF - Food Biophysics

IS - 2

ER -