Gitta Wörtwein

2019

Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

Runegaard, A. H., Jensen, K. L., Wörtwein, G. & Gether, U., 1 Aug 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

Jørgensen, A., Breitenstein, K., Kalliokoski, O., Weimann, A., Henriksen, T., Poulsen, H. E., Jørgensen, M. B. & Wörtwein, G., 14 Dec 2019, In: Acta Neuropsychiatrica. 31, 6, p. 287-293 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2018

Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats

Aalling, N., Hageman, I., Miskowiak, K., Orlowski, D., Wegener, G. & Wortwein, G., Jan 2018, In: Journal of Neuroscience Research. 96, 1, p. 103–116

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats

Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wortwein, G., Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, A., 1 Feb 2018, In: Alcoholism: Clinical and Experimental Research. 42, 2, p. 270-277

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J.-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 1 May 2018, In: eNeuro. 5, 3, 26 p., e0345.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

90 Downloads (Pure)

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

Jensen, K. L., Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, G., Fink-Jensen, A., Madsen, K. L., Daws, L., Gether, U. & Rickhag, M., 1 May 2018, In: eNeuro. 5, 3

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

63 Downloads (Pure)

The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons

Bering, T., Carstensen, M. B., Wörtwein, G., Weikop, P. & Rath, M. F., 1 Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2017

A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats

Jorgensen, A., Kalliokoski, O., Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, J., Wörtwein, G., Poulsen, H. E. & Jorgensen, M. B., 1 Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats

Olesen, M. V., Wörtwein, G., Folke, J. & Pakkenberg, B., 1 Jan 2017, In: Hippocampus. 27, 1, p. 52-60 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser

Translated title of the contribution: Erythropoietin treatment may improve cognition in neuropsychiatric disordersKjær, K. S., Hageman, I., Wörtwein, G., Jørgensen, M. B. & Miskowiak, K. W., 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

Runegaard, A. H., Jensen, K. L., Dencker, D., Wörtwein, G. & Gether, U., 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

2016

5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

Rasmussen, N. B., Olesen, M. V., Brudek, T., Plenge, P., Klein, A. B., Westin, J. E., Fog, K., Wörtwein, G. & Aznar, S., 2016, In: Parkinson’s Disease. 2016, 8 p., 3682936.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

90 Downloads (Pure)

Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, G., Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, A., Torres, G. E. & Galli, A., 17 May 2016, In: Translational Psychiatry. 6, 11 p., e809.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

74 Downloads (Pure)

2015

Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

Gram, M. G., Wogensen, E., Wörtwein, G., Mogensen, J. & Rytter, H. M., 30 Oct 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Dynamic regulation of cerebral DNA repair genes by psychological stress

Forsberg, K., Aalling, N., Wörtwein, G., Loft, S., Møller, P., Hau, J., Hageman, I., Jørgensen, M. B. & Jørgensen, A., 5 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Electroconvulsive Stimulation, but not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus: A Stereological Study

Olesen, M. V., Wörtwein, G. & Pakkenberg, B., 1 Jan 2015, In: Hippocampus. 25, 1, p. 72-80 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Enhanced self-administration of alcohol in muscarinic acetylcholine M₄ receptor knockout mice

de la Cour, C., Sørensen, G., Wörtwein, G., Weikop, P., Nielsen, D. D., Fink-Jensen, A. & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

Dencker, D., Woertwein, G., Lysne, C., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE

Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, G., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

Sorensen, G., Reddy, I. A., Weikop, P., Graham, D. L., Stanwood, G. D., Wörtwein, G., Galli, A. & Fink-Jensen, A., 1 Oct 2015, In: Physiology & Behavior. 149, p. 262-268 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

2014

Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, G. & Woldbye, D. P. D., Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice

Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, G. & Woldbye, D. P. D., Oct 2014, In: Synapse. 68, 10, p. 427-36 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2013

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

Rickhag, K. M., Hansen, F. H., Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, K. L., Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E.-M., Gomeza, J., Woldbye, D. P. D., Wörtwein, G. & Gether, U., 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage

Jorgensen, A., Maigaard, K., Wörtwein, G., Hageman, I., Henriksen, T., Weimann, A., Moller, P., Loft, S., Hau, J., Poulsen, H. E. & Jorgensen, M. B., 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

Rickhag, K. M., Owens, W., Winkler, M.-T., Strandfelt, K. N., Rathje, M., Sørensen, G., Andresen, B., Madsen, K. L., Nygaard Jørgensen, T., Wörtwein, G., Woldbye, D. P. D., Sitte, H. H., Daws, L. C. & Gether, U., 20 Sept 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

Sørensen, G., Wörtwein, G., Fink-Jensen, A. & Woldbye, D. P. D., Apr 2013, In: Pharmacology, Biochemistry and Behavior. 105, p. 151-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

2012

An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

Nielsen, D. D., Weikop, P., Sørensen, G., Woldbye, D. P. D., Wörtwein, G., Wess, J. & Fink-Jensen, A., Nov 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

Maigaard, K., Pedersen, I. H., Jørgensen, A., Jørgensen, M. B. & Wörtwein, G., 10 May 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

Dencker, D., Thomsen, M., Wörtwein, G., Weikop, P., Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, A., 15 Feb 2012, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

Sørensen, G., Jensen, M., Weikop, P., Nielsen, D. D., Christiansen, S. H. O., Løland, C. J., Bengtsen, C. H., Petersen, J. H., Fink-Jensen, A., Wörtwein, G. & Woldbye, D. P. D., Aug 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

The effect of subchronic fluoxetine treatment on learning and memory in adolescent rats

Sass, A. & Wörtwein, G., 1 Mar 2012, In: Behavioural Brain Research. 228, 1, p. 169-75 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Time course and duration of changes in K(v)7.2 and K(v)11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations

Hjaeresen, M.-L., Hageman, I., Wörtwein, G. & Jørgensen, M. B., Jan 2012, In: Brain Stimulation. 5, 1, p. 55-60 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2011

Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.

Fink-Jensen, A., Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, G. & Woldbye, D. P. D., 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

Christiansen, S. H. O., Olesen, M. V., Wörtwein, G. & Woldbye, D. P. D., 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

Schmidt, L. S., Thomsen, M., Weikop, P., Nielsen, D. D., Wess, J., Woldbye, D. P. D., Wörtwein, G. & Fink-Jensen, A., Aug 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

Mikrouli, E., Wörtwein, G., Soylu, R., Mathé, A. A. & Petersén, Å., Dec 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline

Dencker, D., Wörtwein, G., Weikop, P., Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, D. P. D., Wess, J. & Fink-Jensen, A., 20 Apr 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Pharmacological characterization of social isolation-induced hyperactivity

Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G. & Steiniger-Brach, B., May 2011, In: Psychopharmacology. 215, 2, p. 257-66 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

Fabricius, K., Steiniger-Brach, B., Helboe, L., Fink-Jensen, A. & Wörtwein, G., May 2011, In: International Journal of Developmental Neuroscience. 29, 3, p. 347-50 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2010

A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C.-X., Fink-Jensen, A., Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y. & Davis, A. A. & 8 others, Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C.-X., Fink-Jensen, A. & Wess, J., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice

Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, D. P. D., Fink-Jensen, A. & Wörtwein, G., Jan 2010, In: Psychopharmacology. 207, 4, p. 547-58 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Increased dopaminergic activity in socially isolated rats: an electrophysiological study

Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G., Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G., Steiniger-Brach, B. & Sotty, F., 27 Sept 2010, In: Neuroscience Letters. 482, 2, p. 117-22 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

2009

Adult Brain and Behavioral Effect of Early Life Maternal Deprivation

Mathe, A. A., El Khoury, A., Gruber, S. H. M., Husum, H., Wörtwein, G. & Arlinde, C., 2009, Beyond neuropsychiatric diagnostics: Symptoms not disorders. Palomo, T., Beninger, R. J., Kostzewa, R. M. & Archer, T. (eds.). Mountain Home, TN, USA: F. P. Graham Publishing Co.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour

Hageman, I., Nielsen, M., Wörtwein, G., Diemer, N. H. & Jorgensen, M. B., 2009, In: Behavioural Brain Research. 196, 1, p. 71-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Mekanismer ved funktionel restitution efter hjerneskader

Wörtwein, G., 2009, Klinisk neuropsykologi. Gade, A., Gerlach, C., Starrfelt, R. & Møller Pedersen, P. (eds.). København: Frydenlund Academic, p. 480-488

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine

Sørensen, G., Wegener, G., Hasselstrøm, J., Hansen, T. V. O., Wörtwein, G., Fink-Jensen, A. & Woldbye, D. P. D., 2009, In: NeuroReport. 20, 11, p. 1023-6 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model

Petersén, A., Wörtwein, G., Gruber, S. H. M., El-Khoury, A. & Mathé, A. A., 2009, In: Neuroscience Letters. 451, 2, p. 148-51 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2008

Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels

Christensen, R., Marcussen, A. B., Wörtwein, G., Knudsen, G. M. & Aznar, S., 2008, In: Experimental Neurology. 210, 1, p. 164-71 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice

Sørensen, G., Sager, T. N., Petersen, J. H., Brennum, L. T., Thøgersen, P., Hee Bengtsen, C., Thomsen, M., Wörtwein, G., Fink-Jensen, A. & Woldbye, D. P. D., 2008, In: Psychopharmacology. 199, 1, p. 37-46 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex.

Hjæresen, M.-L., Hageman, I., Wörtwein, G., Plenge, P., Jørgensen, M. B. & Wörtwein, G., 2008, In: Brain Research. 1217C, p. 179-184 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Gitta Wörtwein

Research output

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