Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
Staphylococcus aureus is the leading cause of bacterial infections in developed countries and Methicillin-Resistant S. aureus (MRSA) is one of the most significant antibiotic resistant bacteria world-wide. For this reason, my research is dedicated to unravel the molecular mechanisms underlying the ability of Staphylococcus aureus to cause disease and to develop antibiotic resistance. Focus has been on the highly conserved ClpP proteases and Clp chaperones that we have shown to be absolutely essential for the virulence of Staphylococcus aureus. We are currently investigating how the Clp proteases and chaperones central activities such as:
- Virulence gene regulation
- Antibiotic resistance
- Cell division
The long-term objective of my research is to provide the scientific basis for the development of drugs interfering with these mechanisms.
CV
Academic Degrees
cand. scient (1994) University of Copenhangen; Ph. D. (2000) KVL, Department of Food Science
Employments
2000-2003 Assistant professor at the Department of Veterinary Microbiology (KVL).
2003-present Associate professor at the Department of Veterinary Pathobiology KVL (from January the 1 st 2007 KU)
Emneord
- Det Sundhedsvidenskabelige Fakultet
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Dorte Frees er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 6 Lignende profiler
Publikation
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Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, D. & Ingmer, H., 2019, I: Microbiology Spectrum. 7, 2, 23 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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SosA inhibits cell division in Staphylococcus aureus in response to DNA damage
Bojer, M. S., Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, D., Veening, J. W., Foster, S. J. & Ingmer, H., 1 okt. 2019, I: Molecular Microbiology. 112, 4, s. 1116-1130Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, D., 2019, I: Scientific Reports. 9, 11 s., 16456.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis
Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, L., Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, D., 2019, I: PLOS Pathogens. 15, 9, 27 s., e1008044.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
Baldry, M., Nakamura, Y., Nakagawa, S., Frees, D., Matsue, H., Nunez, G. & Ingmer, H., 14 aug. 2018, I: Journal of Infectious Diseases. 218, 6, s. 1009-1013Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study
Nielsen, O. L., Larsen, M. N., Frees, D., Pedersen, M. M., Skov, S. & Olsen, L. H., 2017.Publikation: Konferencebidrag › Konferenceabstrakt til konference › Formidling
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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, D., 1 dec. 2017, I: Scientific Reports. 7, 14 s., 11739.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri
Korbut, R., Mehrdana, F., Kania, P. W., Larsen, M. H., Frees, D., Dalsgaard, I. & Jørgensen, L. V. G., 12 jul. 2016, I: P L o S One. 11, 7, e0158968.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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The ClpP proteases control processes of vital importance for the pathogenesis of Staphylococcus aureus
Frees, D. (Foredragsholder)
3 okt. 2007Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
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Regulated proteolysis controls vital processes in Staphylococcus aureus
Frees, D. (Foredragsholder)
5 sep. 2007Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
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Synthesis and activity of the alternative sigma factor, SigB is serely reduced in Staphylococcus aureus cells lacking the ClpP protease
Frees, D. (Foredragsholder)
23 maj 2007Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
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A possible role of ClpP proteases and chaperones in regulating activity of SigmaB
Frees, D. (Foredragsholder)
23 jan. 2007Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
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FEMS Immunology & Medical Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Udgivelse af peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Udgivelse af peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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FEMS Microbiology Letters (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Udgivelse af peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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Journal of Applied Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Udgivelse af peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning