Cord Herbert Brakebusch

Research output

Research output per year 1990 2001 2002 2003 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2017 2018 2019 2019

• 161 Journal article
• 5 Book chapter
• 3 Review
• 2 Comment/debate
• 2 More
  • 1 Anthology
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2000

  The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

  Iba, K., Albrechtsen, R., Gilpin, B., Frohlich, C., Loechel, F., Zolkiewska, A., Ishiguro, K., Kojima, T., Liu, W., Langford, J. K., Sanderson, R. D., Brakebusch, C., Fässler, R. & Wewer, U. M., 2000, In: Journal of Cell Biology. 149, 5, p. 1143-56 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta1 100%
  • Syndecans 89%
  • Disintegrins 75%
  • Metalloproteases 61%
  • Cysteine 54%
  215 Citations (Scopus)
• 1999

  Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.

  Brakebusch, C., Wennerberg, K., Krell, H. W., Weidle, U. H., Sallmyr, A., Johansson, S. & Fässler, R., 1999, In: Oncogene. 18, 26, p. 3852-61 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta1 100%
  • Fibroblasts 42%
  • Neoplasm Metastasis 35%
  • Neoplasms 18%
  • Integrins 12%
  23 Citations (Scopus)

• Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.

  Gimond, C., van Der Flier, A., van Delft, S., Brakebusch, C., Kuikman, I., Collard, J. G., Fässler, R. & Sonnenberg, A., 1999, In: Journal of Cell Biology. 147, 6, p. 1325-40 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta1 100%
  • Catenins 72%
  • rho GTP-Binding Proteins 72%
  • Cadherins 58%
  • Epithelial Cells 41%
  129 Citations (Scopus)

• Integrin gene targeting.

  Talts, J. F., Brakebusch, C. & Fässler, R., 1999, In: Methods in Molecular Biology. 129, p. 153-87 34 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  28 Citations (Scopus)

• Isolation and functional characterization of the human 90K promoter.

  Brakebusch, C., Sures, I., Jallal, B., Mossie, K., Fusco, O., Iacobelli, S. & Ullrich, A., 1999, In: Genomics. 57, 2, p. 268-78 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Poly I 100%
  • Poly C 90%
  • Transcription Initiation Site 47%
  • Interferons 37%
  • 5' Flanking Region 24%
  11 Citations (Scopus)
• 1998

  90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.

  Fusco, O., Querzoli, P., Nenci, I., Natoli, C., Brakebusch, C. H., Ullrich, A. & Iacobelli, S., 1998, In: International Journal of Cancer. 79, 1, p. 23-6 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gene expression 100%
  • blood cells 99%
  • breast 77%
  • cancer 69%
  • tumors 61%
  33 Citations (Scopus)

• Differential effect on TCR:CD3 stimulation of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger receptor cysteine-rich domain protein family.

  Silvestri, B., Calderazzo, F., Coppola, V., Rosato, A., Iacobelli, S., Natoli, C., Ullrich, A., Sures, I., Azam, M., Brakebusch, C. H., Chieco-Bianchi, L. & Amadori, A., 1998, In: Clinical and Experimental Immunology. 113, 3, p. 394-400 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Scavenger Receptors 100%
  • T-Cell Antigen Receptor 78%
  • Protein Domains 77%
  • Cysteine 72%
  • Glycoproteins 65%
  19 Citations (Scopus)

• Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

  Sasaki, T., Brakebusch, C., Engel, J. & Timpl, R., 1998, In: EMBO Journal. 17, 6, p. 1606-13 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta1 100%
  • human TAA90K protein 81%
  • Fibronectin 69%
  • Extracellular Matrix Proteins 64%
  • Fibronectins 56%
  196 Citations (Scopus)
• 1997

  Beta 1 integrin is essential for teratoma growth and angiogenesis.

  Bloch, W., Forsberg, E., Lentini, S., Brakebusch, C., Martin, K., Krell, H. W., Weidle, U. H., Addicks, K. & Fässler, R., 1997, In: Journal of Cell Biology. 139, 1, p. 265-78 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta Chains 100%
  • Teratoma 79%
  • Growth 34%
  • Embryonic Stem Cells 28%
  • Embryoid Bodies 21%
  163 Citations (Scopus)

• Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.

  Brakebusch, C., Jallal, B., Fusco, O., Iacobelli, S. & Ullrich, A., 1997, In: Journal of Biological Chemistry. 272, 6, p. 3674-82 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Antioncogenic 100%
  • Glycoprotein 43%
  • Transcription Initiation Site 37%
  • Binding Site 33%
  • Interferon Regulatory Factor-1 24%
  11 Citations (Scopus)

• Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.

  Brakebusch, C., Hirsch, E., Potocnik, A. & Fässler, R., 1997, In: Journal of Cell Science. 110 ( Pt 23), p. 2895-904 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Integrin beta1 100%
  • Cell Adhesion Molecules 63%
  • Integrins 32%
  • Extracellular Matrix Proteins 25%
  • Homologous Recombination 12%
  90 Citations (Scopus)

• Sequence and chromosomal localization of the mouse brevican gene.

  Rauch, U., Meyer, H., Brakebusch, C., Seidenbecher, C., Gundelfinger, E. D., Beier, D. R. & Fässler, R., 1997, In: Genomics. 44, 1, p. 15-21 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brevican 100%
  • Genes 22%
  • Exons 17%
  • Introns 13%
  • Protein Isoforms 11%
  21 Citations (Scopus)
• 1995

  Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions.

  Schuchmann, M., Hess, S., Bufler, P., Brakebusch, C., Wallach, D., Porter, A., Riethmüller, G. & Engelmann, H., 1995, In: European Journal of Immunology. 25, 8, p. 2183-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lymphotoxin-alpha 100%
  • Tumor Necrosis Factor-alpha 54%
  • Cytokines 39%
  • NIH 3T3 Cells 16%
  • Cell Surface Receptors 13%
  25 Citations (Scopus)

• Suppression of tumor growth in vivo by local and systemic 90K level increase.

  Jallal, B., Powell, J., Zachwieja, J., Brakebusch, C., Germain, L., Jacobs, J., Iacobelli, S. & Ullrich, A., 1995, In: Cancer Research. 55, 15, p. 3223-7 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Growth 100%
  • mammary carcinoma antigen 87%
  • Nude Mice 74%
  • Neoplasms 64%
  • Vascular Cell Adhesion Molecule-1 45%
  61 Citations (Scopus)
• 1994

  Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

  Bigda, J., Beletsky, I., Brakebusch, C., Varfolomeev, Y., Engelmann, H., Bigda, J., Holtmann, H. & Wallach, D., 1994, In: Journal of Experimental Medicine. 180, 2, p. 445-60 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tumor Necrosis Factor Receptors 100%
  • Tumor Necrosis Factor-alpha 61%
  • Antibodies 48%
  • HeLa Cells 17%
  • Membranes 10%
  129 Citations (Scopus)

• Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor.

  Brakebusch, C., Varfolomeev, E. E., Batkin, M. & Wallach, D., 1994, In: Journal of Biological Chemistry. 269, 51, p. 32488-96 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tumor Necrosis Factor Receptors 100%
  • Amino Acid Sequence 80%
  • Cysteine 54%
  • Mutation 49%
  • Peptide Hydrolases 48%
  93 Citations (Scopus)
• 1992

  Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

  Brakebusch, C., Nophar, Y., Kemper, O., Engelmann, H. & Wallach, D., 1992, In: EMBO Journal. 11, 3, p. 943-50 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Phorbol 13-Acetate 12-Myristate 100%
  • Tumor Necrosis Factor Receptors 75%
  • Tumor Necrosis Factor-alpha 47%
  • phorbol-12-myristate 38%
  • Acetates 32%
  143 Citations (Scopus)

• Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells.

  Winzen, R., Wallach, D., Engelmann, H., Nophar, Y., Brakebusch, C., Kemper, O., Resch, K. & Holtmann, H., 1992, In: Journal of Immunology. 148, 11, p. 3454-60 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • recombinant human tumor necrosis factor-binding protein-1 100%
  • HL-60 Cells 73%
  • Granulocytes 62%
  • Macrophages 43%
  • Messenger RNA 35%
  45 Citations (Scopus)

• Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

  Aderka, D., Engelmann, H., Maor, Y., Brakebusch, C. & Wallach, D., 1992, In: Journal of Experimental Medicine. 175, 2, p. 323-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tumor Necrosis Factor Receptors 100%
  • Tumor Necrosis Factor-alpha 61%
  • Tumor Necrosis Factor Inhibitors 11%
  • Cytokines 6%
  736 Citations (Scopus)
• 1991

  Mechanisms controlling the level of receptors for tumor necrosis factor.

  Holtmann, H., Brakebusch, C., König, M., Klocke, R., Winzen, R., Resch, K. & Wallach, D., 1991, In: Agents and Actions. 32, 1-2, p. 106-8 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  5 Citations (Scopus)

• Soluble and cell surface receptors for tumor necrosis factor.

  Wallach, D., Engelmann, H., Nophar, Y., Aderka, D., Kemper, O., Hornik, V., Holtmann, H. & Brakebusch, C., 1991, In: Agents and actions. Supplements. 35, p. 51-7 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Surface Receptors 100%
  • Tumor Necrosis Factor-alpha 65%
  • Tumor Necrosis Factor Receptors 42%
  • Cysteine 34%
  • Nerve Growth Factor Receptor 24%
  49 Citations (Scopus)
• 1990

  Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

  Engelmann, H., Holtmann, H., Brakebusch, C., Avni, Y. S., Sarov, I., Nophar, Y., Hadas, E., Leitner, O. & Wallach, D., 1990, In: Journal of Biological Chemistry. 265, 24, p. 14497-504 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tumor Necrosis Factor Receptors 100%
  • Tumor Necrosis Factor-alpha 61%
  • Antibodies 48%
  • Protein 35%
  • Carrier Proteins 30%
  341 Citations (Scopus)

• Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

  Nophar, Y., Kemper, O., Brakebusch, C., Englemann, H., Zwang, R., Aderka, D., Holtmann, H. & Wallach, D., 1990, In: EMBO Journal. 9, 10, p. 3269-78 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tumor Necrosis Factor Receptors 100%
  • Complementary DNA 90%
  • Amino Acid Sequence 80%
  • Tumor Necrosis Factor-alpha 61%
  • Carrier Proteins 49%
  286 Citations (Scopus)