Suppression of tumor growth in vivo by local and systemic 90K level increase.

B Jallal; J Powell; J Zachwieja; C Brakebusch; L Germain; J Jacobs; S Iacobelli; A Ullrich

Suppression of tumor growth in vivo by local and systemic 90K level increase.

B Jallal, J Powell, J Zachwieja, C Brakebusch, L Germain, J Jacobs, S Iacobelli, A Ullrich

Department of Biomedical Sciences

61 Citations (Scopus)

Abstract

Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.

Original language	English
Journal	Cancer Research
Volume	55
Issue number	15
Pages (from-to)	3223-7
Number of pages	4
ISSN	0008-5472
Publication status	Published - 1995

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{d6686bd0595611dd8d9f000ea68e967b,

title = "Suppression of tumor growth in vivo by local and systemic 90K level increase.",

abstract = "Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.",

author = "B Jallal and J Powell and J Zachwieja and C Brakebusch and L Germain and J Jacobs and S Iacobelli and A Ullrich",

note = "Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1",

year = "1995",

language = "English",

volume = "55",

pages = "3223--7",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research",

number = "15",

}

TY - JOUR

T1 - Suppression of tumor growth in vivo by local and systemic 90K level increase.

AU - Jallal, B

AU - Powell, J

AU - Zachwieja, J

AU - Brakebusch, C

AU - Germain, L

AU - Jacobs, J

AU - Iacobelli, S

AU - Ullrich, A

N1 - Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1

PY - 1995

Y1 - 1995

N2 - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.

AB - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.

M3 - Journal article

C2 - 7542166

SN - 0008-5472

VL - 55

SP - 3223

EP - 3227

JO - Cancer Research

JF - Cancer Research

IS - 15

ER -

Suppression of tumor growth in vivo by local and systemic 90K level increase.

Abstract

UN SDGs

Fingerprint

Cite this