Clare Louise Hawkins

2019

8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

Tang, V., Fu, S., Rayner, B. S. & Hawkins, C. L., Sept 2019, In: Redox Biology. 26, 11 p., UNSP 101274.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

3 Downloads (Pure)

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, C. L., 17 Jun 2019, In: Chemical Research in Toxicology. 32, 6, p. 1223-1234

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

Reyes, L., Hawkins, C. L. & Rayner, B. S., 15 Apr 2019, In: Nitric Oxide: Biology and Chemistry. 665, p. 132-142

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, C. L., Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 19 Feb 2019, In: Biochemistry. 58, 7, p. 974-986

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

Cai, H., Chuang, C. Y., Vanichkitrungruang, S., Hawkins, C. L. & Davies, M. J., Apr 2019, In: Free Radical Biology and Medicine. 134, p. 526-536

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, C. L., Nov 2019, In: Journal of Visualized Experiments. 153, e60541 .

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

Vanichkitrungruang, S., Chuang, C. Y., Hawkins, C. L., Hammer, A., Hoefler, G., Malle, E. & Davies, M. J., 20 May 2019, In: Free Radical Biology and Medicine. 136, p. 118-134

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2018

A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, C., 15 Mar 2018, In: Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

Hawkins, C. L., Aug 2018, In: Acta Physiologica. 223, 4, 3 p., e13106 .

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, C. L., Bao, S., Wise, S. G. & Bilek, M. M. M., 31 Oct 2018, In: Applied Surface Science. 456, p. 701-710

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

Hawkins, C. L., Jul 2018, In: Kidney International. 94, 1, p. 12-14

Research output: Contribution to journal › Comment/debate › Research › peer-review

5 Citations (Scopus)

Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, C. L., Dec 2018, In: Free Radical Biology and Medicine. 129, p. 25-34

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]

Chiang, S., Anzovino, A., Brown, B. E., Hawkins, C. L., Richardson, D. R. & Huang, M. L. -H., 2018, In: Free Radical Biology and Medicine. 120, p. S35-S35 OP-19 .

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2017

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J. & Hawkins, C. L., 1 Aug 2017, In: Redox Biology. 12, p. 872-882 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

102 Downloads (Pure)

CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis

Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, C., Prosser, H. C. G. & Bursill, C. A., Mar 2017, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, C. L., Oct 2017, In: Redox Biology. 13, p. 623-632 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

65 Downloads (Pure)

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis

Anzovino, A., Chiang, S., Brown, B. E., Hawkins, C. L., Richardson, D. R. & Huang, M. L-H., Dec 2017, In: American Journal of Pathology. 187, 12, p. 2858-2875 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

Indo, H. P., Hawkins, C. L., Nakanishi, I., Matsumoto, K-I., Matsui, H., Suenaga, S., Davies, M. J., St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

28 Citations (Scopus)

2016

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, C. L. & Richardson, D. R., 30 Dec 2016, In: The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, M. J. & Hawkins, C. L., 1 May 2016, In: Free Radical Biology & Medicine. 94, p. 88-98 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, C. L., Davies, M. J., Clair, D. K. S. & Mukai, C., 23 Dec 2016, In: Scientific Reports. 6, 10 p., 39015.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

71 Downloads (Pure)

Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

Tweeddale, H. J., Hawkins, C. L., Janmie, J. F., Truscott, R. J. W. & Davies, M. J., 2 Oct 2016, In: Free Radical Research. 50, 10, p. 1116-1130 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, M. J. & Hawkins, C. L., Dec 2016, In: P L o S One. 11, 12, 16 p., e0168844.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

Karimi Galougahi, K., Liu, C-C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, C. L. & Figtree, G. A., 1 Feb 2016, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2015

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, C. L., Davies, M. J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In: Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J. & Hawkins, C. L., 2 Apr 2015, In: Free Radical Biology & Medicine. 84, p. 279-288 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2014

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

Rayner, B. S., Love, D. T. & Hawkins, C. L., Jun 2014, In: Free Radical Biology & Medicine. 71, p. 240-55 16 p.

Research output: Contribution to journal › Journal article › Commissioned › peer-review

66 Citations (Scopus)

Detection and characterisation of radicals in biological materials using EPR methodology

Hawkins, C. L. & Davies, M. J., Feb 2014, In: B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.

Research output: Contribution to journal › Review › peer-review

122 Citations (Scopus)

Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

Galougahi, K. K., Liu, C-C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, M. J., Hawkins, C. L., Rasmussen, H. H. & Figtree, G. A., 2014, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, C. L. & Davies, M. J., May 2014, In: Free Radical Biology & Medicine. 70, p. 96-105 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Hawkins, C. L., 5 Nov 2014, In: Kidney International. 86, 5, p. 875-7 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, M. J., Hawkins, C. L. & Ashby, M. T., 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 1-11 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2013

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, M. J. & Hawkins, C. L., Dec 2013, In: Free Radical Biology & Medicine. 65, p. 1352-62 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K-A., Davies, M. J. & Hawkins, C. L., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

2012

Hypothiocyanous acid - benign or deadly?

Barrett, T. J. & Hawkins, C. L., 20 Feb 2012, In: Chemical Research in Toxicology. 25, 2, p. 263-73 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

63 Citations (Scopus)

Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

Summers, F. A., Forsman Quigley, A. & Hawkins, C. L., 24 Aug 2012, In: Biochemical and Biophysical Research Communications. 425, 2, p. 157-61 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, M. J. & Hawkins, C. L., 15 Mar 2012, In: Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes

Lok, H. C., Suryo Rahmanto, Y., Hawkins, C. L., Kalinowski, D. S., Morrow, C. S., Townsend, A. J., Ponka, P. & Richardson, D. R., 2 Jan 2012, In: The Journal of Biological Chemistry. 287, 1, p. 607-18 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

Pattison, D. I., Davies, M. J. & Hawkins, C. L., Aug 2012, In: Free Radical Research. 46, 8, p. 975-95 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

102 Citations (Scopus)

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

Boon, A-C., Hawkins, C. L., Bisht, K., Coombes, J. S., Bakrania, B., Wagner, K-H. & Bulmer, A. C., 15 May 2012, In: Free Radical Biology & Medicine. 52, 10, p. 2120-7 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

2011

Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, C. L. & Davies, M. J., 15 Jan 2011, In: Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, C. L. & Davies, M. J., 1 Nov 2011, In: Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity

Yu, Y., Suryo Rahmanto, Y., Hawkins, C. L. & Richardson, D. R., Jun 2011, In: Molecular Pharmacology. 79, 6, p. 921-31 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

2010

Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents

Stanley, N. R., Pattison, D. I. & Hawkins, C. L., 19 Jul 2010, In: Chemical Research in Toxicology. 23, 7, p. 1293-302 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, C. L., Rees, M. D. & Davies, M. J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

Cellular effects of peptide and protein hydroperoxides

Rahmanto, A. S., Morgan, P. E., Hawkins, C. L. & Davies, M. J., 15 Apr 2010, In: Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

Rahmanto, A. S., Morgan, P. E., Hawkins, C. L. & Davies, M. J., 30 Nov 2010, In: Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study

Jansson, P. J., Hawkins, C. L., Lovejoy, D. B. & Richardson, D. R., Nov 2010, In: Journal of Inorganic Biochemistry. 104, 11, p. 1224-8 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

Lane, A. E., Tan, J. T. M., Hawkins, C. L., Heather, A. K. & Davies, M. J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

2009

Quantification of protein modification by oxidants

Hawkins, C. L., Morgan, P. E. & Davies, M. J., 15 Apr 2009, In: Free Radical Biology & Medicine. 46, 8, p. 965-88 24 p.

Research output: Contribution to journal › Journal article › Research › peer-review

319 Citations (Scopus)

Clare Louise Hawkins

Research output

Search results