Abstract
Hypothiocyanous acid (HOSCN) is produced in biological systems by the peroxidase-catalyzed reaction of thiocyanate (SCN -) with H 2O 2. This oxidant plays an important role in the human immune system, owing to its potent bacteriostatic properties. Significant amounts of HOSCN are also formed by immune cells under inflammatory conditions, yet the reactivity of this oxidant with host tissue is poorly characterized. Traditionally, HOSCN has been viewed as a mild oxidant, which is innocuous to mammalian cells. Indeed, recent studies show that the presence of SCN in airways has a protective (Figure presented) function, by preventing the formation of other, more damaging, inflammatory oxidants. However, there is an increasing body of evidence that challenges this dogma, showing that the selectivity of HOSCN for specific thiol-containing cellular targets results in the initiation of significant cellular damage. This propensity to induce cellular dysfunction is gaining considerable interest, particularly in the cardiovascular field, as smokers have elevated plasma SCN -, the precursor for HOSCN. his review will outline the beneficial and detrimental aspects of HOSCN formation in biological systems.
| Original language | English |
|---|---|
| Journal | Chemical Research in Toxicology |
| Volume | 25 |
| Issue number | 2 |
| Pages (from-to) | 263-73 |
| Number of pages | 11 |
| ISSN | 0893-228X |
| DOIs | |
| Publication status | Published - 20 Feb 2012 |
| Externally published | Yes |
Keywords
- Animals
- Cardiovascular Diseases
- Cystic Fibrosis
- Humans
- Lung
- Mouth
- Thiocyanates
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
