Clare Louise Hawkins

2019

8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

Tang, V., Fu, S., Rayner, B. S. & Hawkins, C. L., sep. 2019, I: Redox Biology. 26, 11 s., UNSP 101274.

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9 Citationer (Scopus)

3 Downloads (Pure)

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, C. L., 17 jun. 2019, I: Chemical Research in Toxicology. 32, 6, s. 1223-1234

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2 Citationer (Scopus)

Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

Reyes, L., Hawkins, C. L. & Rayner, B. S., 15 apr. 2019, I: Nitric Oxide: Biology and Chemistry. 665, s. 132-142

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7 Citationer (Scopus)

Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, C. L., Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 19 feb. 2019, I: Biochemistry. 58, 7, s. 974-986

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10 Citationer (Scopus)

Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

Cai, H., Chuang, C. Y., Vanichkitrungruang, S., Hawkins, C. L. & Davies, M. J., apr. 2019, I: Free Radical Biology and Medicine. 134, s. 526-536

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13 Citationer (Scopus)

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, C. L., nov. 2019, I: Journal of Visualized Experiments. 153, e60541 .

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2 Citationer (Scopus)

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

Vanichkitrungruang, S., Chuang, C. Y., Hawkins, C. L., Hammer, A., Hoefler, G., Malle, E. & Davies, M. J., 20 maj 2019, I: Free Radical Biology and Medicine. 136, s. 118-134

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13 Citationer (Scopus)

2018

A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, C., 15 mar. 2018, I: Archives of Biochemistry and Biophysics. 642, s. 23-30 8 s.

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8 Citationer (Scopus)

A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

Hawkins, C. L., aug. 2018, I: Acta Physiologica. 223, 4, 3 s., e13106 .

Publikation: Bidrag til tidsskrift › Leder › peer review

1 Citationer (Scopus)

Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, C. L., Bao, S., Wise, S. G. & Bilek, M. M. M., 31 okt. 2018, I: Applied Surface Science. 456, s. 701-710

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8 Citationer (Scopus)

Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

Hawkins, C. L., jul. 2018, I: Kidney International. 94, 1, s. 12-14

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5 Citationer (Scopus)

Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, C. L., dec. 2018, I: Free Radical Biology and Medicine. 129, s. 25-34

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11 Citationer (Scopus)

The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]

Chiang, S., Anzovino, A., Brown, B. E., Hawkins, C. L., Richardson, D. R. & Huang, M. L.-H., 2018, I: Free Radical Biology and Medicine. 120, s. S35-S35 OP-19 .

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2017

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J. & Hawkins, C. L., 1 aug. 2017, I: Redox Biology. 12, s. 872-882 12 s.

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17 Citationer (Scopus)

102 Downloads (Pure)

CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis

Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, C., Prosser, H. C. G. & Bursill, C. A., mar. 2017, I: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, s. 1179-1192 14 s.

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6 Citationer (Scopus)

Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, C. L., okt. 2017, I: Redox Biology. 13, s. 623-632 10 s.

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16 Citationer (Scopus)

65 Downloads (Pure)

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis

Anzovino, A., Chiang, S., Brown, B. E., Hawkins, C. L., Richardson, D. R. & Huang, M.L.-H., dec. 2017, I: American Journal of Pathology. 187, 12, s. 2858-2875 18 s.

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30 Citationer (Scopus)

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

Indo, H. P., Hawkins, C. L., Nakanishi, I., Matsumoto, K.-I., Matsui, H., Suenaga, S., Davies, M. J., St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Bind 240. s. 439-456 18 s. (Handbook of Experimental Pharmacology, Bind 240).

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

28 Citationer (Scopus)

2016

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, C. L. & Richardson, D. R., 30 dec. 2016, I: The Journal of Biological Chemistry. 291, 53, s. 27042-27061 20 s.

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23 Citationer (Scopus)

Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, M. J. & Hawkins, C. L., 1 maj 2016, I: Free Radical Biology & Medicine. 94, s. 88-98 11 s.

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23 Citationer (Scopus)

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, C. L., Davies, M. J., Clair, D. K. S. & Mukai, C., 23 dec. 2016, I: Scientific Reports. 6, 10 s., 39015.

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12 Citationer (Scopus)

71 Downloads (Pure)

Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

Tweeddale, H. J., Hawkins, C. L., Janmie, J. F., Truscott, R. J. W. & Davies, M. J., 2 okt. 2016, I: Free Radical Research. 50, 10, s. 1116-1130 15 s.

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17 Citationer (Scopus)

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, M. J. & Hawkins, C. L., dec. 2016, I: P L o S One. 11, 12, 16 s., e0168844.

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10 Citationer (Scopus)

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

Karimi Galougahi, K., Liu, C.-C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, C. L. & Figtree, G. A., 1 feb. 2016, I: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.

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18 Citationer (Scopus)

2015

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, C. L., Davies, M. J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 jul. 2015, I: Journal of Clinical Biochemistry and Nutrition. 57, 1, s. 13-20 8 s.

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5 Citationer (Scopus)

Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J. & Hawkins, C. L., 2 apr. 2015, I: Free Radical Biology & Medicine. 84, s. 279-288 10 s.

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18 Citationer (Scopus)

2014

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

Rayner, B. S., Love, D. T. & Hawkins, C. L., jun. 2014, I: Free Radical Biology & Medicine. 71, s. 240-55 16 s.

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66 Citationer (Scopus)

Detection and characterisation of radicals in biological materials using EPR methodology

Hawkins, C. L. & Davies, M. J., feb. 2014, I: B B A - Reviews on Cancer. 1840, 2, s. 708-21 14 s.

Publikation: Bidrag til tidsskrift › Review › peer review

122 Citationer (Scopus)

Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

Galougahi, K. K., Liu, C.-C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, M. J., Hawkins, C. L., Rasmussen, H. H. & Figtree, G. A., 2014, I: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, s. e000731

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51 Citationer (Scopus)

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K.-I., Fu, S., Bottle, S. E., Hawkins, C. L. & Davies, M. J., maj 2014, I: Free Radical Biology & Medicine. 70, s. 96-105 10 s.

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28 Citationer (Scopus)

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Hawkins, C. L., 5 nov. 2014, I: Kidney International. 86, 5, s. 875-7 3 s.

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6 Citationer (Scopus)

Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, M. J., Hawkins, C. L. & Ashby, M. T., 15 dec. 2014, I: Archives of Biochemistry and Biophysics. 564, s. 1-11 11 s.

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6 Citationer (Scopus)

2013

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, M. J. & Hawkins, C. L., dec. 2013, I: Free Radical Biology & Medicine. 65, s. 1352-62 11 s.

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34 Citationer (Scopus)

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K.-A., Davies, M. J. & Hawkins, C. L., 15 jan. 2013, I: Biochemical Journal. 449, 2, s. 531-42 12 s.

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42 Citationer (Scopus)

2012

Hypothiocyanous acid - benign or deadly?

Barrett, T. J. & Hawkins, C. L., 20 feb. 2012, I: Chemical Research in Toxicology. 25, 2, s. 263-73 11 s.

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63 Citationer (Scopus)

Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

Summers, F. A., Forsman Quigley, A. & Hawkins, C. L., 24 aug. 2012, I: Biochemical and Biophysical Research Communications. 425, 2, s. 157-61 5 s.

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26 Citationer (Scopus)

Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, M. J. & Hawkins, C. L., 15 mar. 2012, I: Free Radical Biology & Medicine. 52, 6, s. 1075-85 11 s.

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42 Citationer (Scopus)

Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes

Lok, H. C., Suryo Rahmanto, Y., Hawkins, C. L., Kalinowski, D. S., Morrow, C. S., Townsend, A. J., Ponka, P. & Richardson, D. R., 2 jan. 2012, I: The Journal of Biological Chemistry. 287, 1, s. 607-18 12 s.

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43 Citationer (Scopus)

Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

Pattison, D. I., Davies, M. J. & Hawkins, C. L., aug. 2012, I: Free Radical Research. 46, 8, s. 975-95 21 s.

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102 Citationer (Scopus)

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

Boon, A.-C., Hawkins, C. L., Bisht, K., Coombes, J. S., Bakrania, B., Wagner, K.-H. & Bulmer, A. C., 15 maj 2012, I: Free Radical Biology & Medicine. 52, 10, s. 2120-7 8 s.

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62 Citationer (Scopus)

2011

Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, C. L. & Davies, M. J., 15 jan. 2011, I: Free Radical Biology & Medicine. 50, 2, s. 389-99 11 s.

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15 Citationer (Scopus)

High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, C. L. & Davies, M. J., 1 nov. 2011, I: Free Radical Biology & Medicine. 51, 9, s. 1815-22 8 s.

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53 Citationer (Scopus)

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity

Yu, Y., Suryo Rahmanto, Y., Hawkins, C. L. & Richardson, D. R., jun. 2011, I: Molecular Pharmacology. 79, 6, s. 921-31 11 s.

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38 Citationer (Scopus)

2010

Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents

Stanley, N. R., Pattison, D. I. & Hawkins, C. L., 19 jul. 2010, I: Chemical Research in Toxicology. 23, 7, s. 1293-302 10 s.

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52 Citationer (Scopus)

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, C. L., Rees, M. D. & Davies, M. J., 15 apr. 2010, I: Biochemical Pharmacology. 79, 8, s. 1156-64 9 s.

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50 Citationer (Scopus)

Cellular effects of peptide and protein hydroperoxides

Rahmanto, A. S., Morgan, P. E., Hawkins, C. L. & Davies, M. J., 15 apr. 2010, I: Free Radical Biology & Medicine. 48, 8, s. 1071-8 8 s.

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36 Citationer (Scopus)

Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

Rahmanto, A. S., Morgan, P. E., Hawkins, C. L. & Davies, M. J., 30 nov. 2010, I: Free Radical Biology & Medicine. 49, 10, s. 1505-15 11 s.

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27 Citationer (Scopus)

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study

Jansson, P. J., Hawkins, C. L., Lovejoy, D. B. & Richardson, D. R., nov. 2010, I: Journal of Inorganic Biochemistry. 104, 11, s. 1224-8 5 s.

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47 Citationer (Scopus)

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

Lane, A. E., Tan, J. T. M., Hawkins, C. L., Heather, A. K. & Davies, M. J., 15 aug. 2010, I: Biochemical Journal. 430, 1, s. 161-9 9 s.

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59 Citationer (Scopus)

2009

Quantification of protein modification by oxidants

Hawkins, C. L., Morgan, P. E. & Davies, M. J., 15 apr. 2009, I: Free Radical Biology & Medicine. 46, 8, s. 965-88 24 s.

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319 Citationer (Scopus)

Clare Louise Hawkins

Publikation

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