Andreas Toft Sørensen

2019

Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, N. W., Jørgensen, S. H., McGirr, J. C., de Diego Ajenjo, A., Sørensen, A. T., Perrier, J.-F., Petersen, A., Gether, U., Woldbye, D. P. D. & Andreasen, J. T., 2 Mar 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

Runegaard, A. H., Fitzpatrick, C. M., Woldbye, D. P. D., Andreasen, J. T., Sørensen, A. T. & Gether, U., 1 Apr 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.

Research output: Contribution to journal › Review › peer-review

18 Citations (Scopus)

The C-terminal flanking peptide of neuropeptide Y (NPY) is not essential for seizure-suppressant actions of prepro-NPY overexpression in male rats

Soud, K., Jørgensen, S. H., Woldbye, D. P. D. & Sørensen, A. T., Mar 2019, In: Journal of Neuroscience Research. 97, 3, p. 362-372 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

2018

Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females

Dolzani, S. D., Baratta, M. V., Moss, J. M., Leslie, N. L., Tilden, S. G., Sørensen, A. T., Watkins, L. R., Lin, Y. & Maier, S. F., 1 Jan 2018, In: eNeuro. 5, 1, p. 1-18 18 p., e0025-18.2018.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

50 Downloads (Pure)

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J.-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 1 May 2018, In: eNeuro. 5, 3, 26 p., e0345.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

90 Downloads (Pure)

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

Weng, F.-J., Garcia, R. I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., Rich, D., Garcia-Dominguez, D., Hung, M., Yelhekar, T. D., Sørensen, A. T., Xu, W., Chung, K., Castillo, P. E. & Lin, Y., 7 Mar 2018, In: Neuron. 97, 5, p. 1137-1152 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2017

Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons

Sørensen, A. T., Ledri, M., Melis, M., Nikitidou Ledri, L., Andersson, M. & Kokaia, M., 1 Nov 2017, In: eNeuro. 4, 6, e0172-17.2017 1–10.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

50 Downloads (Pure)

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research

Jørgensen, S. H., Fitzpatrick, C. M., Gether, U., Woldbye, D. P. D. & Sørensen, A. T., Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

2016

A robust activity marking system for exploring active neuronal ensembles

Sorensen, A. T., Cooper, Y. A., Baratta, M. V., Weng, F.-J., Zhang, Y., Ramamoorthi, K., Fropf, R., LaVerriere, E., Xue, J., Young, A., Schneider, C., Gotzsche, C. R., Hemberg, M., Yin, J. C. P., Maier, S. F. & Lin, Y., 23 Sept 2016, In: eLife. 5, 9, 28 p., e13918.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

97 Downloads (Pure)

2015

Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus

Ledri, M., Sorensen, A. T., Madsen, M. G., Christiansen, S. H., Ledri, L. N., Cifra, A., Bengzon, J., Lindberg, E., Pinborg, L. H., Jespersen, B., Gotzsche, C. R., Woldbye, D. P. D., Andersson, M. & Kokaia, M., 1 Jul 2015, In: Journal of Neuroscience. 35, 26, p. 9622-9631 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2014

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Chuong, A. S., Miri, M. L., Busskamp, V., Matthews, G. A. C., Acker, L. C., Sørensen, A. T., Young, A., Klapoetke, N. C., Henninger, M. A., Kodandaramaiah, S. B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C. R., Chow, B. Y., Han, X., Lin, Y., Tye, K. M. & Roska, B. & 2 others, Cardin, J. A. & Boyden, E. S., Aug 2014, In: Nature Neuroscience. 17, 8, p. 1123-1129 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

281 Citations (Scopus)

Optogenetic inhibition of chemically induced hypersynchronized bursting in mice

Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., May 2014, In: Neurobiology of Disease. 65, p. 133-141 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors

Avaliani, N., Sørensen, A. T., Ledri, M., Bengzon, J., Koch, P., Brüstle, O., Deisseroth, K., Andersson, M. & Kokaia, M., 1 Dec 2014, In: Stem Cells. 32, 12, p. 3088-98 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

2013

Jasper’s Basic mechanisms of the Epilepsies: Gene Therapy of Focal-Onset Epilepsy Using Adeno-Associated Virus Vector-Mediated Overexpression of Neuropeptide Y

Noe, F., Sørensen, A. T., Kokaia, M. & Vezzani, A., 2013, Jasper's Basic Mechanisms of the Epilepsies: Gene Therapy of Focal-Onset Epilepsy Using Adeno-Associated Virus Vector-Mediated Overexpression of Neuropeptide Y. Noebels, J. L., Avoli, M., Rogawski, M. A., Olsen, R. W. & Delgado-Escueta, A. V. (eds.). 4 ed. Oxford University Press, p. 1139-1149 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Novel approaches to epilepsy treatment

Sørensen, A. T. & Kokaia, M., Jan 2013, In: Epilepsia. 54, 1, p. 1-10 10 p.

Research output: Contribution to journal › Review › peer-review

54 Citations (Scopus)

2012

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.

Gøtzsche, C. R., Nikitidou, L., Sørensen, A. T., Olesen, M. V., Sørensen, G., Christiansen, S. H. O., Ängehagen, M., Woldbye, D. P. D. & Kokaia, M., Jan 2012, In: Neurobiology of Disease. 45, p. 288-96 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

2011

Activity-dependent long-term plasticity of afferent synapses on grafted stem/progenitor cell-derived neurons

Sørensen, A. T., Rogelius, N., Lundberg, C. & Kokaia, M., Jun 2011, In: Experimental Neurology. 229, 2, p. 274-81 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model

Tønnesen, J., Parish, C. L., Sørensen, A. T., Andersson, A., Lundberg, C., Deisseroth, K., Arenas, E., Lindvall, O. & Kokaia, M., 4 Mar 2011, In: PLOS ONE. 6, 3, p. e17560

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

The treatment of neurological diseases under a new light: the importance of optogenetics

Kokaia, M. & Sørensen, A. T., Jan 2011, In: Drugs of Today. 47, 1, p. 53-62 10 p.

Research output: Contribution to journal › Review › peer-review

11 Citations (Scopus)

Tuning afferent synapses of hippocampal interneurons by neuropeptide Y

Ledri, M., Sørensen, A. T., Erdelyi, F., Szabo, G. & Kokaia, M., Feb 2011, In: Hippocampus. 21, 2, p. 198-211 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

2010

Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures

Woldbye, D. P. D., Ängehagen, M., Gøtzsche, C. R., Elbrønd-Bek, H., Sørensen, A. T., Christiansen, S. H. O., Olesen, M. V., Nikitidou, L., Hansen, T. V. O., Kanter-Schlifke, I. & Kokaia, M., Sept 2010, In: Brain. 133, 9, p. 2778-88 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

2009

Encyclopedia of Basic Epilepsy Research: Epilepsy and Gene Therapy: Resculpturing synaptic transmission with neuropeptides

Kokaia, M. & Sørensen, A. T., 27 May 2009, Encyclopedia of Basic Epilepsy Research: Epilepsy and Gene Therapy: Resculpturing synaptic transmission with neuropeptides. Schwartzkroin, P. (ed.). Elsevier Ltd. Academic Press, Vol. 3. p. 1430-34 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review

8 Citations (Scopus)

Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP

Sørensen, A. T., Nikitidou, L., Ledri, M., Lin, E.-J. D., During, M. J., Kanter-Schlifke, I. & Kokaia, M., Feb 2009, In: Experimental Neurology. 215, 2, p. 328-33 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

Optogenetic control of epileptiform activity

Tønnesen, J., Sørensen, A. T., Deisseroth, K., Lundberg, C. & Kokaia, M., 21 Jul 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 29, p. 12162-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

175 Citations (Scopus)

2008

Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

Sørensen, A. T., Kanter-Schlifke, I., Lin, E.-J. D., During, M. J. & Kokaia, M., Oct 2008, In: Molecular and Cellular Neuroscience. 39, 2, p. 229-37 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

Sørensen, A. T., Kanter-Schlifke, I., Carli, M., Balducci, C., Noe, F., During, M. J., Vezzani, A. & Kokaia, M., 2008, In: Hippocampus. 18, 6, p. 564-74 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice

Parish, C. L., Castelo-Branco, G., Rawal, N., Tonnesen, J., Sorensen, A. T., Salto, C., Kokaia, M., Lindvall, O. & Arenas, E., Jan 2008, In: The Journal of Clinical Investigation. 118, 1, p. 149-60 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

133 Citations (Scopus)

2007

Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity

Kanter-Schlifke, I., Toft Sørensen, A., Ledri, M., Kuteeva, E., Hökfelt, T. & Kokaia, M., 19 Dec 2007, In: Neuroscience. 150, 4, p. 984-92 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

2005

Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors

Woldbye, D. P. D., Nanobashvili, A., Sørensen, A. V., Husum, H., Bolwig, T. G., Sørensen, G., Ernfors, P., Kokaia, M. & Sørensen, G., 1 Dec 2005, In: Neurobiology of Disease. 20, 3, p. 760-72 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts

Sørensen, A. T., Thompson, L., Kirik, D., Björklund, A., Lindvall, O. & Kokaia, M., May 2005, In: European Journal of Neuroscience. 21, 10, p. 2793-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Andreas Toft Sørensen

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