Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Franco Cortese; Dmitry Klokov; Andreyan Osipov; Jakub Stefaniak; Alexey Moskalev; Jane Schastnaya; Charles Cantor; Alexander Aliper; Polina Mamoshina; Igor Ushakov; Alex Sapetsky; Quentin Vanhaelen; Irina Alchinova; Mikhail Karganov; Olga Kovalchuk; Ruth Wilkins; Andrey Shtemberg; Marjan Moreels; Sarah Baatout; Evgeny Izumchenko; João Pedro de Magalhães; Artem V. Artemov; Sylvain V. Costes; Afshin Beheshti; Xiao Wen Mao; Michael J. Pecaut; Dmitry Kaminskiy; Ivan V. Ozerov; Morten Scheibye-Knudsen; Alex Zhavoronkov

doi:10.18632/oncotarget.24461

Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Franco Cortese, Dmitry Klokov, Andreyan Osipov, Jakub Stefaniak, Alexey Moskalev, Jane Schastnaya, Charles Cantor, Alexander Aliper, Polina Mamoshina, Igor Ushakov, Alex Sapetsky, Quentin Vanhaelen, Irina Alchinova, Mikhail Karganov, Olga Kovalchuk, Ruth Wilkins, Andrey Shtemberg, Marjan Moreels, Sarah Baatout, Evgeny IzumchenkoJoão Pedro de Magalhães, Artem V. Artemov, Sylvain V. Costes, Afshin Beheshti, Xiao Wen Mao, Michael J. Pecaut, Dmitry Kaminskiy, Ivan V. Ozerov^*, Morten Scheibye-Knudsen, Alex Zhavoronkov

^*Corresponding author af dette arbejde

32 Citationer (Scopus)

70 Downloads (Pure)

Abstract

While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

Originalsprog	Engelsk
Tidsskrift	OncoTarget
Vol/bind	9
Udgave nummer	18
Sider (fra-til)	14692-14722
Antal sider	31
ISSN	1949-2553
DOI	https://doi.org/10.18632/oncotarget.24461
Status	Udgivet - 2018

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10.18632/oncotarget.24461Licens: CC BY

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonizationForlagets udgivne version, 3,43 MBLicens: CC BY

Citationsformater

Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., ... Zhavoronkov, A. (2018). Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. OncoTarget, 9(18), 14692-14722. https://doi.org/10.18632/oncotarget.24461

Cortese, F, Klokov, D, Osipov, A, Stefaniak, J, Moskalev, A, Schastnaya, J, Cantor, C, Aliper, A, Mamoshina, P, Ushakov, I, Sapetsky, A, Vanhaelen, Q, Alchinova, I, Karganov, M, Kovalchuk, O, Wilkins, R, Shtemberg, A, Moreels, M, Baatout, S, Izumchenko, E, de Magalhães, JP, Artemov, AV, Costes, SV, Beheshti, A, Mao, XW, Pecaut, MJ, Kaminskiy, D, Ozerov, IV, Scheibye-Knudsen, M & Zhavoronkov, A 2018, 'Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization', OncoTarget, bind 9, nr. 18, s. 14692-14722. https://doi.org/10.18632/oncotarget.24461

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title = "Vive la radior{\'e}sistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization",

abstract = "While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.",

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author = "Franco Cortese and Dmitry Klokov and Andreyan Osipov and Jakub Stefaniak and Alexey Moskalev and Jane Schastnaya and Charles Cantor and Alexander Aliper and Polina Mamoshina and Igor Ushakov and Alex Sapetsky and Quentin Vanhaelen and Irina Alchinova and Mikhail Karganov and Olga Kovalchuk and Ruth Wilkins and Andrey Shtemberg and Marjan Moreels and Sarah Baatout and Evgeny Izumchenko and {de Magalh{\~a}es}, {Jo{\~a}o Pedro} and Artemov, {Artem V.} and Costes, {Sylvain V.} and Afshin Beheshti and Mao, {Xiao Wen} and Pecaut, {Michael J.} and Dmitry Kaminskiy and Ozerov, {Ivan V.} and Morten Scheibye-Knudsen and Alex Zhavoronkov",

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T2 - Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

AU - Cortese, Franco

AU - Klokov, Dmitry

AU - Osipov, Andreyan

AU - Stefaniak, Jakub

AU - Moskalev, Alexey

AU - Schastnaya, Jane

AU - Cantor, Charles

AU - Aliper, Alexander

AU - Mamoshina, Polina

AU - Ushakov, Igor

AU - Sapetsky, Alex

AU - Vanhaelen, Quentin

AU - Alchinova, Irina

AU - Karganov, Mikhail

AU - Kovalchuk, Olga

AU - Wilkins, Ruth

AU - Shtemberg, Andrey

AU - Moreels, Marjan

AU - Baatout, Sarah

AU - Izumchenko, Evgeny

AU - de Magalhães, João Pedro

AU - Artemov, Artem V.

AU - Costes, Sylvain V.

AU - Beheshti, Afshin

AU - Mao, Xiao Wen

AU - Pecaut, Michael J.

AU - Kaminskiy, Dmitry

AU - Ozerov, Ivan V.

AU - Scheibye-Knudsen, Morten

AU - Zhavoronkov, Alex

PY - 2018

Y1 - 2018

N2 - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

AB - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

KW - DNA damage

KW - Longevity

KW - Mars mission

KW - Radioresistance

KW - Space exploration

U2 - 10.18632/oncotarget.24461

DO - 10.18632/oncotarget.24461

M3 - Journal article

C2 - 29581875

AN - SCOPUS:85042923493

SN - 1949-2553

VL - 9

SP - 14692

EP - 14722

JO - Oncotarget

JF - Oncotarget

IS - 18

ER -

Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

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