TY - JOUR
T1 - UV-guided screening of benzodiazepine producing species in Penicillium
AU - Ostenfeld Larsen T, null
AU - Frydenvang, Karla Andrea
AU - Christian Frisvad J, null
PY - 2000
Y1 - 2000
N2 - The benzodiazepine sclerotigenin (auranthine B) recently described as a metabolite of Penicillium sclerotigenum, has been isolated as the major metabolite from an isolate of P. commune. The structure of sclerotigenin was established by a single-crystal X-ray diffraction study and by NMR spectroscopy. UV-guided screening for benzodiazepine production by other penicillia revealed that sclerotigenin was also produced by isolates of P. clavigerum, P. lanosum, P. melanoconidium, P. sclerotigenum and P. verrucosum. Sclerotigenin was detected both intra- and extracellularly. Apparently, P. aurantiogriseum is the only auranthine producing species in genus Penicillium.
AB - The benzodiazepine sclerotigenin (auranthine B) recently described as a metabolite of Penicillium sclerotigenum, has been isolated as the major metabolite from an isolate of P. commune. The structure of sclerotigenin was established by a single-crystal X-ray diffraction study and by NMR spectroscopy. UV-guided screening for benzodiazepine production by other penicillia revealed that sclerotigenin was also produced by isolates of P. clavigerum, P. lanosum, P. melanoconidium, P. sclerotigenum and P. verrucosum. Sclerotigenin was detected both intra- and extracellularly. Apparently, P. aurantiogriseum is the only auranthine producing species in genus Penicillium.
U2 - 10.1016/s0305-1978(99)00126-x
DO - 10.1016/s0305-1978(99)00126-x
M3 - Journal article
C2 - 10913849
SN - 0305-1978
VL - 28
SP - 881
EP - 886
JO - Biochemical Systematics and Ecology
JF - Biochemical Systematics and Ecology
IS - 9
ER -