UV-guided screening of benzodiazepine producing species in Penicillium

TY - JOUR

T1 - UV-guided screening of benzodiazepine producing species in Penicillium

AU - Ostenfeld Larsen T, null

AU - Frydenvang, Karla Andrea

AU - Christian Frisvad J, null

PY - 2000

Y1 - 2000

N2 - The benzodiazepine sclerotigenin (auranthine B) recently described as a metabolite of Penicillium sclerotigenum, has been isolated as the major metabolite from an isolate of P. commune. The structure of sclerotigenin was established by a single-crystal X-ray diffraction study and by NMR spectroscopy. UV-guided screening for benzodiazepine production by other penicillia revealed that sclerotigenin was also produced by isolates of P. clavigerum, P. lanosum, P. melanoconidium, P. sclerotigenum and P. verrucosum. Sclerotigenin was detected both intra- and extracellularly. Apparently, P. aurantiogriseum is the only auranthine producing species in genus Penicillium.

AB - The benzodiazepine sclerotigenin (auranthine B) recently described as a metabolite of Penicillium sclerotigenum, has been isolated as the major metabolite from an isolate of P. commune. The structure of sclerotigenin was established by a single-crystal X-ray diffraction study and by NMR spectroscopy. UV-guided screening for benzodiazepine production by other penicillia revealed that sclerotigenin was also produced by isolates of P. clavigerum, P. lanosum, P. melanoconidium, P. sclerotigenum and P. verrucosum. Sclerotigenin was detected both intra- and extracellularly. Apparently, P. aurantiogriseum is the only auranthine producing species in genus Penicillium.

U2 - 10.1016/s0305-1978(99)00126-x

DO - 10.1016/s0305-1978(99)00126-x

M3 - Journal article

C2 - 10913849

SN - 0305-1978

VL - 28

SP - 881

EP - 886

JO - Biochemical Systematics and Ecology

JF - Biochemical Systematics and Ecology

IS - 9

ER -