The plasma membrane H+-ATPase, a simple polypeptide with a long history

Michael Palmgren; Pierre Morsomme

doi:10.1002/yea.3365

The plasma membrane H⁺-ATPase, a simple polypeptide with a long history

Michael Palmgren^*, Pierre Morsomme

^*Corresponding author af dette arbejde

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Abstract

The plasma membrane H⁺-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit F_OF₁ ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H⁺-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of F_OF₁ ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H⁺-ATPases of fungi and plants has a long history, which is briefly summarized in this review.

Originalsprog	Engelsk
Tidsskrift	Yeast
Vol/bind	36
Udgave nummer	4
Sider (fra-til)	201-210
ISSN	0749-503X
DOI	https://doi.org/10.1002/yea.3365
Status	Udgivet - apr. 2019

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10.1002/yea.3365Licens: CC BY

yea.3365Forlagets udgivne version, 275 KBLicens: CC BY

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abstract = "The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.",

keywords = "Arabidopsis thaliana, F-type ATPase, Neurospora crassa, Nicotiana tabacum, P-type ATPase, proton pump, Saccharomyces cerevisiae, Schizosaccharomyces pombe",

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AU - Morsomme, Pierre

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KW - Neurospora crassa

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KW - P-type ATPase

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KW - Saccharomyces cerevisiae

KW - Schizosaccharomyces pombe

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