The plasma membrane H+-ATPase, a simple polypeptide with a long history

Michael Palmgren; Pierre Morsomme

doi:10.1002/yea.3365

The plasma membrane H⁺-ATPase, a simple polypeptide with a long history

Michael Palmgren^*, Pierre Morsomme

^*Corresponding author for this work

Section for Transport Biology

9 Citations (Scopus)

7 Downloads (Pure)

Abstract

The plasma membrane H⁺-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit F_OF₁ ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H⁺-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of F_OF₁ ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H⁺-ATPases of fungi and plants has a long history, which is briefly summarized in this review.

Original language	English
Journal	Yeast
Volume	36
Issue number	4
Pages (from-to)	201-210
ISSN	0749-503X
DOIs	https://doi.org/10.1002/yea.3365
Publication status	Published - Apr 2019

Keywords

Arabidopsis thaliana
F-type ATPase
Neurospora crassa
Nicotiana tabacum
P-type ATPase
proton pump
Saccharomyces cerevisiae
Schizosaccharomyces pombe

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abstract = "The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.",

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KW - Arabidopsis thaliana

KW - F-type ATPase

KW - Neurospora crassa

KW - Nicotiana tabacum

KW - P-type ATPase

KW - proton pump

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KW - Schizosaccharomyces pombe

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The plasma membrane H⁺-ATPase, a simple polypeptide with a long history

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Keywords

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