The importance of mitochondrial DNA in aging and cancer

TY - JOUR

T1 - The importance of mitochondrial DNA in aging and cancer

AU - Madsen, Claus Desler

AU - Espersen, Maiken Lise Marcker

AU - Singh, Keshav K

AU - Rasmussen, Lene Juel

PY - 2011/3/30

Y1 - 2011/3/30

N2 - Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.

AB - Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.

U2 - 10.4061/2011/407536

DO - 10.4061/2011/407536

M3 - Journal article

C2 - 21584235

SN - 2090-2204

VL - 2011

SP - 407536

JO - Journal of Aging Research

JF - Journal of Aging Research

ER -