TY - JOUR
T1 - The importance of mitochondrial DNA in aging and cancer
AU - Madsen, Claus Desler
AU - Espersen, Maiken Lise Marcker
AU - Singh, Keshav K
AU - Rasmussen, Lene Juel
PY - 2011/3/30
Y1 - 2011/3/30
N2 - Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.
AB - Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.
U2 - 10.4061/2011/407536
DO - 10.4061/2011/407536
M3 - Journal article
C2 - 21584235
SN - 2090-2204
VL - 2011
SP - 407536
JO - Journal of Aging Research
JF - Journal of Aging Research
ER -
