Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

TY - JOUR

T1 - Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

AU - Rubal, Juan J

AU - Guerra, Francisco M

AU - Moreno-Dorado, F Javier

AU - Jorge, Zacarías D

AU - Massanet, Guillermo M

AU - Søhoel, Helmer

AU - Smitt, Ulla W

AU - Frydenvang, Karla Andrea

AU - Christensen, S Brøgger

AU - Nielsen, Charlotte

AU - Eriksson, Margit

PY - 2006

Y1 - 2006

N2 - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

AB - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

KW - Crystallography, X-Ray

KW - Molecular Conformation

KW - Molecular Structure

KW - Plant Roots

KW - Plants, Medicinal

KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases

KW - Sesquiterpenes

KW - Spain

KW - Thapsia

U2 - 10.1021/np0603065

DO - 10.1021/np0603065

M3 - Journal article

C2 - 17125222

SN - 0163-3864

VL - 69

SP - 1566

EP - 1571

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -