Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

Juan J Rubal; Francisco M Guerra; F Javier Moreno-Dorado; Zacarías D Jorge; Guillermo M Massanet; Helmer Søhoel; Ulla W Smitt; Karla Andrea Frydenvang; S Brøgger Christensen; Charlotte Nielsen; Margit Eriksson

doi:10.1021/np0603065

Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

Juan J Rubal, Francisco M Guerra, F Javier Moreno-Dorado, Zacarías D Jorge, Guillermo M Massanet, Helmer Søhoel, Ulla W Smitt, Karla Andrea Frydenvang, S Brøgger Christensen, Charlotte Nielsen, Margit Eriksson

7 Citations (Scopus)

Abstract

Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

Original language	English
Journal	Journal of Natural Products
Volume	69
Issue number	11
Pages (from-to)	1566-71
Number of pages	6
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np0603065
Publication status	Published - 2006

Keywords

Crystallography, X-Ray
Molecular Conformation
Molecular Structure
Plant Roots
Plants, Medicinal
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Sesquiterpenes
Spain
Thapsia

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10.1021/np0603065

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@article{ea84007869a04d01a6580370d2f99c7e,

title = "Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida",

abstract = "Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.",

keywords = "Crystallography, X-Ray, Molecular Conformation, Molecular Structure, Plant Roots, Plants, Medicinal, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sesquiterpenes, Spain, Thapsia",

author = "Rubal, {Juan J} and Guerra, {Francisco M} and Moreno-Dorado, {F Javier} and Jorge, {Zacar{\'i}as D} and Massanet, {Guillermo M} and Helmer S{\o}hoel and Smitt, {Ulla W} and Frydenvang, {Karla Andrea} and Christensen, {S Br{\o}gger} and Charlotte Nielsen and Margit Eriksson",

year = "2006",

doi = "10.1021/np0603065",

language = "English",

volume = "69",

pages = "1566--71",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

AU - Rubal, Juan J

AU - Guerra, Francisco M

AU - Moreno-Dorado, F Javier

AU - Jorge, Zacarías D

AU - Massanet, Guillermo M

AU - Søhoel, Helmer

AU - Smitt, Ulla W

AU - Frydenvang, Karla Andrea

AU - Christensen, S Brøgger

AU - Nielsen, Charlotte

AU - Eriksson, Margit

PY - 2006

Y1 - 2006

N2 - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

AB - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.

KW - Crystallography, X-Ray

KW - Molecular Conformation

KW - Molecular Structure

KW - Plant Roots

KW - Plants, Medicinal

KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases

KW - Sesquiterpenes

KW - Spain

KW - Thapsia

U2 - 10.1021/np0603065

DO - 10.1021/np0603065

M3 - Journal article

C2 - 17125222

SN - 0163-3864

VL - 69

SP - 1566

EP - 1571

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

Abstract

Keywords

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