Sarcopenia, Aging and Prospective Interventional Strategies

Tyler B Waltz; Elayne M Fivenson; Marya Morevati; Chuanhao Li; Kevin G Becker; Vilhelm A Bohr; Evandro F Fang

doi:10.2174/0929867324666170801095850

Sarcopenia, Aging and Prospective Interventional Strategies

Tyler B Waltz, Elayne M Fivenson, Marya Morevati, Chuanhao Li, Kevin G Becker, Vilhelm A Bohr, Evandro F Fang

15 Citationer (Scopus)

Abstract

Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

Originalsprog	Engelsk
Tidsskrift	Current Medicinal Chemistry
Vol/bind	25
Udgave nummer	40
Sider (fra-til)	5588-5596
Antal sider	9
ISSN	0929-8673
DOI	https://doi.org/10.2174/0929867324666170801095850
Status	Udgivet - 2018

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10.2174/0929867324666170801095850

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792375/pdf/nihms899961.pdfLicens: Andet

Citationsformater

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title = "Sarcopenia, Aging and Prospective Interventional Strategies",

abstract = "Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.",

author = "Waltz, {Tyler B} and Fivenson, {Elayne M} and Marya Morevati and Chuanhao Li and Becker, {Kevin G} and Bohr, {Vilhelm A} and Fang, {Evandro F}",

note = "Copyright{\textcopyright} Bentham Science Publishers; For any queries, please email at [email protected].",

year = "2018",

doi = "10.2174/0929867324666170801095850",

language = "English",

volume = "25",

pages = "5588--5596",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",

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TY - JOUR

T1 - Sarcopenia, Aging and Prospective Interventional Strategies

AU - Waltz, Tyler B

AU - Fivenson, Elayne M

AU - Morevati, Marya

AU - Li, Chuanhao

AU - Becker, Kevin G

AU - Bohr, Vilhelm A

AU - Fang, Evandro F

PY - 2018

Y1 - 2018

N2 - Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

AB - Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

U2 - 10.2174/0929867324666170801095850

DO - 10.2174/0929867324666170801095850

M3 - Review

C2 - 28762310

SN - 0929-8673

VL - 25

SP - 5588

EP - 5596

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 40

ER -

Sarcopenia, Aging and Prospective Interventional Strategies

Abstract

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