Sarcopenia, Aging and Prospective Interventional Strategies

Tyler B Waltz; Elayne M Fivenson; Marya Morevati; Chuanhao Li; Kevin G Becker; Vilhelm A Bohr; Evandro F Fang

doi:10.2174/0929867324666170801095850

Sarcopenia, Aging and Prospective Interventional Strategies

Tyler B Waltz, Elayne M Fivenson, Marya Morevati, Chuanhao Li, Kevin G Becker, Vilhelm A Bohr, Evandro F Fang

15 Citations (Scopus)

Abstract

Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

Original language	English
Journal	Current Medicinal Chemistry
Volume	25
Issue number	40
Pages (from-to)	5588-5596
Number of pages	9
ISSN	0929-8673
DOIs	https://doi.org/10.2174/0929867324666170801095850
Publication status	Published - 2018

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title = "Sarcopenia, Aging and Prospective Interventional Strategies",

abstract = "Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.",

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T1 - Sarcopenia, Aging and Prospective Interventional Strategies

AU - Waltz, Tyler B

AU - Fivenson, Elayne M

AU - Morevati, Marya

AU - Li, Chuanhao

AU - Becker, Kevin G

AU - Bohr, Vilhelm A

AU - Fang, Evandro F

PY - 2018

Y1 - 2018

N2 - Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

AB - Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

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DO - 10.2174/0929867324666170801095850

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SN - 0929-8673

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SP - 5588

EP - 5596

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 40

ER -

Sarcopenia, Aging and Prospective Interventional Strategies

Abstract

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