Rat retinal vasomotion assessed by laser speckle imaging

Anastasiia Y Neganova; Dmitry D Postnov; Olga Sosnovtseva; Jens Christian B Jacobsen

doi:10.1371/journal.pone.0173805

Rat retinal vasomotion assessed by laser speckle imaging

Anastasiia Y Neganova, Dmitry D Postnov, Olga Sosnovtseva, Jens Christian B Jacobsen

Nyre- og Karforskning

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Abstract

Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

Originalsprog	Engelsk
Artikelnummer	e0173805
Tidsskrift	PloS one
Vol/bind	12
Udgave nummer	3
Antal sider	13
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0173805
Status	Udgivet - mar. 2017

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10.1371/journal.pone.0173805Licens: CC BY

Rat retinal vasomotion assessed by laser speckle imagingForlagets udgivne version, 3,02 MBLicens: CC BY

Citationsformater

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AU - Jacobsen, Jens Christian B

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N2 - Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

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Rat retinal vasomotion assessed by laser speckle imaging

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