Rat retinal vasomotion assessed by laser speckle imaging

Anastasiia Y Neganova; Dmitry D Postnov; Olga Sosnovtseva; Jens Christian B Jacobsen

doi:10.1371/journal.pone.0173805

Rat retinal vasomotion assessed by laser speckle imaging

Anastasiia Y Neganova, Dmitry D Postnov, Olga Sosnovtseva, Jens Christian B Jacobsen

Renal and Vascular Research

9 Citations (Scopus)

77 Downloads (Pure)

Abstract

Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

Original language	English
Article number	e0173805
Journal	PloS one
Volume	12
Issue number	3
Number of pages	13
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0173805
Publication status	Published - Mar 2017

Keywords

Journal Article

Access to Document

10.1371/journal.pone.0173805Licence: CC BY

Rat retinal vasomotion assessed by laser speckle imagingFinal published version, 3.02 MBLicence: CC BY

Cite this

@article{e69a1b1924b144afb66462f11526ff19,

title = "Rat retinal vasomotion assessed by laser speckle imaging",

abstract = "Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.",

keywords = "Journal Article",

author = "Neganova, {Anastasiia Y} and Postnov, {Dmitry D} and Olga Sosnovtseva and Jacobsen, {Jens Christian B}",

year = "2017",

month = mar,

doi = "10.1371/journal.pone.0173805",

language = "English",

volume = "12",

journal = "PloS one",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "3",

}

TY - JOUR

T1 - Rat retinal vasomotion assessed by laser speckle imaging

AU - Neganova, Anastasiia Y

AU - Postnov, Dmitry D

AU - Sosnovtseva, Olga

AU - Jacobsen, Jens Christian B

PY - 2017/3

Y1 - 2017/3

N2 - Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

AB - Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

KW - Journal Article

U2 - 10.1371/journal.pone.0173805

DO - 10.1371/journal.pone.0173805

M3 - Journal article

C2 - 28339503

SN - 1932-6203

VL - 12

JO - PloS one

JF - PloS one

IS - 3

M1 - e0173805

ER -

Rat retinal vasomotion assessed by laser speckle imaging

Abstract

Keywords

Access to Document

Fingerprint

Cite this