R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

TY - JOUR

T1 - R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

AU - Millard, Peter S.

AU - Kragelund, Birthe B.

AU - Burow, Meike

N1 - Copyright © 2019. Published by Elsevier Ltd.

PY - 2019/10

Y1 - 2019/10

N2 - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.

AB - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.

U2 - 10.1016/j.tplants.2019.07.003

DO - 10.1016/j.tplants.2019.07.003

M3 - Review

C2 - 31358471

SN - 1360-1385

VL - 24

SP - 934

EP - 946

JO - Trends in Plant Science

JF - Trends in Plant Science

IS - 10

ER -