TY - JOUR
T1 - R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain
AU - Millard, Peter S.
AU - Kragelund, Birthe B.
AU - Burow, Meike
N1 - Copyright © 2019. Published by Elsevier Ltd.
PY - 2019/10
Y1 - 2019/10
N2 - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.
AB - Several transcription factor (TF) families, including the MYB family, regulate a wide array of biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; although information on protein structure is scarce for plant MYB TFs, various in silico methods suggest that the non-MYB regions contain extensive intrinsically disordered regions (IDRs). Although IDRs do not fold into stable globular structures, they comprise functional regions including interaction motifs, and recent research has shown that IDRs perform crucial biological roles. We map here domain organization, disorder predictions, and functional regions across the entire Arabidopsis thaliana R2R3 MYB TF family, and highlight where an increased research focus will be necessary to shape a new understanding of structure-function relationships in plant TFs.
U2 - 10.1016/j.tplants.2019.07.003
DO - 10.1016/j.tplants.2019.07.003
M3 - Review
C2 - 31358471
SN - 1360-1385
VL - 24
SP - 934
EP - 946
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 10
ER -