Publikationer pr. år
Publikationer pr. år
Thorvaldsensvej 40, 1871 Frederiksberg C
Publikationer pr. år
Associate Professor at DNRF Center DynaMo - Center for Dynamic Molecular Interactions
http://dynamo.ku.dk/people/burow
Research focus: Regulatory Networks and Interactomics
Plants handle environmental perturbation with the help of complex and intricate regulatory networks interconnected through the RNA, protein, and metabolites. To fully understand how plants integrate internal and external signaling cues to mount responses, we study transcriptional regulation (DNA methylation, transcription factor complexes, protein-DNA interactions), post-transcriptional regulation (long regulatory RNAs, microRNA processing), and post-translational regulation (protein modification, protein stability, protein-protein interactions, metabolite sensing), and how all of these levels of control are coordinated to produce a specific phenotype.
Arabidopsis thaliana and its primary defense compounds, the glucosinolates, have been identified as a prime model system to study regulatory networks. Particularly, the chemically diverse methionine-derived glucosinolates have been recognized for their complex and dynamic regulatory network. Three closely related R2R3 MYB transcription factors have been characterized as direct regulators that cooperatively interact to shape the profile of methionine-derived glucosinolates which changes dynamically in time and space. Additional regulatory mechanisms which appear to contribute to controlling glucosinolate levels in the plant include metabolite sensing, RNA-mediated regulation and protein-protein interactions between biosynthetic enzymes to facilitate efficient channeling of pathway intermediates.
Using glucosinolate biosynthesis in Arabidopsis thaliana as a model pathway, my group currently focusses on:
Since 2011
Associate Professor, Department of Plant and Environmental Sciences, UCPH, Denmark
2008 – 2011
Assistant Professor, Department for Plant Biology and Biotechnology, UCPH, Denmark
2006 – 2007
Post-doctoral researcher, Institut für Pharmazeutische Biologie, TU Braunschweig, Germany
2001 – 2006
PhD student, Max Planck Insitute for Chemical Ecology, Jena, Germany
Dipl. Biol. (with excellence), University of Hannover, Germany, Sep. 2001
Dr. rer. nat. (summa cum laude), Friedrich Schiller Universität, Jena, Germany, March 2008
Experimental Molecular Biology I/II (course coordinator)
Biochemistry of Protein Complexes (course coordinator)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Review › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
Burow, M. (Deltager)
Aktivitet: Andre aktivitetstyper › Andet (priser, ekstern undervisning samt andet). - Andet
Burow, M. (Deltager)
Aktivitet: Andre aktivitetstyper › Andet (priser, ekstern undervisning samt andet). - Andet