Orally active-targeted drug delivery systems for proteins and peptides

TY - JOUR

T1 - Orally active-targeted drug delivery systems for proteins and peptides

AU - Li, Xiuying

AU - Yu, Miaorong

AU - Fan, Weiwei

AU - Gan, Yong

AU - Hovgaard, Lars

AU - Yang, Mingshi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Introduction: In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption.Areas covered: This review focuses on recent advances with orally ATDDS, including ligand-protein conjugates, recombinant ligand-protein fusion proteins and ligand-modified carriers. In addition to traditional intestinal active transport systems of substrates and their corresponding receptors, transporters and carriers, new targets such as intercellular adhesion molecule-1 and β-integrin are also discussed.Expert opinion: ATDDS can improve oral absorption of proteins and peptides. However, currently, no clinical studies on ATDDS for proteins and peptides are underway, perhaps due to the complexity and limited knowledge of transport mechanisms. Therefore, more research is warranted to optimize ATDDS efficiency.

AB - Introduction: In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption.Areas covered: This review focuses on recent advances with orally ATDDS, including ligand-protein conjugates, recombinant ligand-protein fusion proteins and ligand-modified carriers. In addition to traditional intestinal active transport systems of substrates and their corresponding receptors, transporters and carriers, new targets such as intercellular adhesion molecule-1 and β-integrin are also discussed.Expert opinion: ATDDS can improve oral absorption of proteins and peptides. However, currently, no clinical studies on ATDDS for proteins and peptides are underway, perhaps due to the complexity and limited knowledge of transport mechanisms. Therefore, more research is warranted to optimize ATDDS efficiency.

KW - Active-targeted drug delivery systems

KW - IgG-Fc receptor

KW - Intercellular adhesion molecule-1

KW - Oral protein and peptide delivery

KW - Proton-coupled folate transporter

KW - Recombinant fusion protein

KW - Transferrin receptor

UR - http://www.scopus.com/inward/record.url?scp=84906316137&partnerID=8YFLogxK

U2 - 10.1517/17425247.2014.924500

DO - 10.1517/17425247.2014.924500

M3 - Review

C2 - 24962803

AN - SCOPUS:84906316137

SN - 1742-5247

VL - 11

SP - 1435

EP - 1447

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

IS - 9

ER -