Abstract
Introduction: In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption.Areas covered: This review focuses on recent advances with orally ATDDS, including ligand-protein conjugates, recombinant ligand-protein fusion proteins and ligand-modified carriers. In addition to traditional intestinal active transport systems of substrates and their corresponding receptors, transporters and carriers, new targets such as intercellular adhesion molecule-1 and β-integrin are also discussed.Expert opinion: ATDDS can improve oral absorption of proteins and peptides. However, currently, no clinical studies on ATDDS for proteins and peptides are underway, perhaps due to the complexity and limited knowledge of transport mechanisms. Therefore, more research is warranted to optimize ATDDS efficiency.
| Original language | English |
|---|---|
| Journal | Expert Opinion on Drug Delivery |
| Volume | 11 |
| Issue number | 9 |
| Pages (from-to) | 1435-1447 |
| Number of pages | 13 |
| ISSN | 1742-5247 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
Keywords
- Active-targeted drug delivery systems
- IgG-Fc receptor
- Intercellular adhesion molecule-1
- Oral protein and peptide delivery
- Proton-coupled folate transporter
- Recombinant fusion protein
- Transferrin receptor