On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry

    7 Citationer (Scopus)

    Abstract

    Sample preparation is an essential step in any bioanalytical procedure and very often the most challenging step in method development. Most of the currently used methods require a relatively large amount of sample and are time consuming. Here, we describe a new approach based on electromembrane extraction (EME) integrated in microfluidic polymer chips. This procedure is fast, requires only small amounts of sample, and may thus be used for monitoring drug metabolism and the formation of metabolites in real time.
    OriginalsprogEngelsk
    TitelMicrochip Capillary Electrophoresis Protocols
    RedaktørerAnn Van Schepdael
    Antal sider12
    Vol/bind1274
    ForlagHumana Press
    Publikationsdato2015
    Sider171-82
    Kapitel15
    ISBN (Trykt)978-1-4939-2352-6
    ISBN (Elektronisk)978-1-4939-2353-3
    DOI
    StatusUdgivet - 2015
    NavnMethods in molecular biology (Clifton, N.J.)

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