On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry

    7 Citations (Scopus)

    Abstract

    Sample preparation is an essential step in any bioanalytical procedure and very often the most challenging step in method development. Most of the currently used methods require a relatively large amount of sample and are time consuming. Here, we describe a new approach based on electromembrane extraction (EME) integrated in microfluidic polymer chips. This procedure is fast, requires only small amounts of sample, and may thus be used for monitoring drug metabolism and the formation of metabolites in real time.

    Original languageEnglish
    Title of host publicationMicrochip Capillary Electrophoresis Protocols
    EditorsAnn Van Schepdael
    Number of pages12
    Volume1274
    PublisherHumana Press
    Publication date2015
    Pages171-82
    Chapter15
    ISBN (Print)978-1-4939-2352-6
    ISBN (Electronic)978-1-4939-2353-3
    DOIs
    Publication statusPublished - 2015
    SeriesMethods in molecular biology (Clifton, N.J.)

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