TY - JOUR
T1 - Mitophagy and Neuroprotection
AU - Lou, Guofeng
AU - Palikaras, Konstantinos
AU - Lautrup, Sofie
AU - Scheibye-Knudsen, Morten
AU - Tavernarakis, Nektarios
AU - Fang, Evandro F.
PY - 2020/1
Y1 - 2020/1
N2 - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.
AB - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.
KW - ageing
KW - Alzheimer's disease
KW - amyotrophic lateral sclerosis
KW - energy homeostasis
KW - mitochondria
KW - mitophagy
KW - neurodegeneration
KW - Parkinson's disease
U2 - 10.1016/j.molmed.2019.07.002
DO - 10.1016/j.molmed.2019.07.002
M3 - Review
C2 - 31375365
AN - SCOPUS:85069854565
SN - 1471-4914
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
ER -